hmgb1和psa联合检测在前列腺癌诊断中的-研究

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1、万方数据新乡医学院硕士学位论文馇里三日木1．Pca组与BPH、健康组三组血清HMGBl水平差异有显著统计学意义(p∞．001)；Pcaflt与BPH、健康组血清PSA差异显著(p<0．001)，BPH组与健康组差异有统计学意义(P--0．028)。2．37例Pea患者中，金标准证实8例患者出现浸润或远处转移，6例患者处于C期：肿瘤已浸润或超出前列腺包膜，2例患者处于D期MRI及全身骨显像提示盆腔淋巴结及远处转移。29例处于A、B两期患者与8例处于C、D两期的患者相比，HMGBl差异有显著统计学意义(仁3．

2、13，／-4)．001)。C期患者与D期患者HMGBl组间差异有统计学意义(P．<0．01)。3．HMGBl单一敏感性和特异性为83％和75％，、而PSA为67％和82％，两者联合时敏感性达到90％，特异性61％，准确度可达80％。结论HMGBl与PSA联合检测两指标可提高诊断前列腺癌的效能。关键词前列腺癌：高迁移率族蛋I兰tBl；前列腺特异性抗原：联合检测2万方数据新乡医学院硕士学位论文TheJointDetectionResearchofHMGBlandPSAin．theDiagnosisofPros

3、taticCancer、AbstractBackgroundProstatecancerisacommonmalignanttumorinelderlymaleurogenitalsystemandtheincidenceinChinaistrendingtorapimyascendinrecentyeats．TheincidenceofprostatecancerinChinahasincreasednearlythreetimesasmuch,rosefrom1．1／1hundred’thousand

4、in1990to4．3／1hundred．thousandin2008烈嬲阻dingtoepidemiologicalinvestigation；data；isexpectedtoreach6．311h喇thousand,in2020．PSA(prostate-specjficantigen)isthemarkerforearlydiscoveryanddetectionofprostaticcancer,butduetothelackofspecificity,misdiagnosismightbepo

5、ssible．TheexpressionofHMGBlinprostaticcancerishigh．HMGBlisassociatedwiththe．growth,invasionandmetastasisofprostaticCanCe：LThejointdetectionofthetwomal'kel'Swillcontributetotheearlydiagnosisofprostaticcancef．ObjectiveTheexpressionofHMGBlandPSAinBPH(benignp

6、rostatichyperplasia)andprostaticcan激andtheirdifferenceweredetectedtoreveal’thecorrelationbetweenthetwo；therelationshipbetweenthejointdetectionofHMGBIandPSAandprostaticcancerWasdiscussedtoprovide．experimentalbasisforrevealingcertainauxiliarydiagnosisofHGMB

7、ltoprostaticcancer．MethodCollectedbloodserumofprostatediseasepatientsconfirmedbymmsrectalprostatebiopsypathologyexaminationorpostoperativepathologyinNo．371HospitalofPLAandXinxiangcentralhospitalfrom201。2t02014：prostatic．cancergroup37cases，BPHgroup34C．．9．s

8、esandthecontrolgroup30cases．Inordertocontrol’thefactorsaffectingtheserumlevelofHMGBIandPS八selectpatientsinstrictaccordancewiththefollowingstandards：1．Patientsagedmo他than50；2．ExcludehepatitisBpatients；3．Noprostatemas