阿托伐他汀对高脂血症患者左心室心肌功能的影响

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1、阿托伐他汀对高脂血症患者左心室心肌功能的影响肖秀娟1张岩1魏海燕1李海朋1庞远1谢艳凤1（1.唐山市协和医院超声科，河北唐山063004）作者简介：肖秀娟，女，1971-，主治医师，通讯地址：唐山市协和医院超声科，河北唐山063004;电话：13831549818；E-mail：xiaoxj2003@126.com[摘要]目的：探讨阿托伐他汀对无冠心病证据高脂血症患者左心室心肌功能的影响。方法：选取21例无冠心病证据的高脂血症患者为研究组，并给予6个月阿托伐他汀20mg/天，同时选取18例性别及年龄相匹配的健康者为对照组，对照组、研究组治

2、疗前和治疗6个月后均接受传统二维彩色多普勒超声心动图、脉冲波组织多普勒成像及背向散射积分检查。结果：与对照组比较，研究组治疗前无论传统二维彩色多普勒超声心动图或是脉冲波组织多普勒成像检查E峰流速和Ea峰值明显降低（P<0.01）、A峰流速和Aa峰值明显增加（P<0.01），E/A和Ea/Aa比值明显降低（P<0.01），且Tei指数均显著增加(P<0.01)；背向散射积分参数（心动周期变化幅度指数）明显降低（P<0.05）。与治疗前比较，研究组治疗后Tei指数明显降低（P<0.01），心动周期变化幅度指数显著增加（P<0.01）。结论：阿

3、托伐他汀长期治疗可改善高脂血症所致的左心室心肌功能损害。[关键词]高脂血症，阿托伐他汀，彩色多普勒心肌成像，背向散射积分，心肌功能TheeffectsofatorvastatinonleftventricularmyocardialfunctioninhypercholesterolemiapatientswithoutcoronaryheartdiseaseXIAOXiujuan1,ZHANGYan1,LIHaipeng1,PANGYuan1,XIEYanfeng1(1.DepartmentofEchocardiography,Tang

4、shanUnionHospital,Tangshan,063004,China)AbstractObjective:Toexploretheeffectsofatorvastatinonleftventricularmyocardialfunctioninhypercholesterolemiapatientswithoutcoronaryheartdisease.Methods:21patientswithhypercholesterolemiaandwithoutevidenceofcoronaryheartdiseaseand18s

5、ex-andage-matchedhealthyvolunteerswerestudied.Allsubjectsweresubmittedtoconventional2Dcolor-Dopplerechocardiography(2D-CDE),pulsedwavetissueDopplerimaging(PWTDI)fortheanalysisofdiastolicfunction,andtointegratedbackscatter(IBS)fortheevaluationofintrinsiccontractilityandtis

6、suecharacterization.Echocardiographicevaluationwasrepeatedaftersixmonthsoftreatmentwithatorvastatin(20mg/day)in21hypercholesterolemiapatients.Results:EpeakvelocityandEawerereduced（P<0.05）,ApeakvelocityandAawereremarklyincreased（P<0.01）.E/AratioandEa/Aaratioweresignificant

7、lylower(P<0.01).Teiindexwereremarklyincreased(P<0.01)inhypercholesterolemiapatients,regardlessof2D-CDEandPWTDIexaminations.CyclicVariationindexinintegratedbackscatterweresignificantlyreduced(P<0.05).Comparedtopre-treatment,Teiindexwereremarklydecreased(P<0.01)andCyclicVar

8、iationindexinintegratedbackscatterweresignificantlyincreased(P<0.01)inhypercholesterolemiapatien