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1、美罗华联合CHOP方案縮EBV阳性弥漫大B细胞淋巴瘤究2018-03-2910:29:48中国现代医生2018年5期蔡岗丽[摘要]戸的評价美罗华联合CHOP方案(环磷酰胺+表阿儘素+长春新碱+强的松)治疗EBV阳性弥漫大B细胞淋巴瘤(DLBCL)的效果,并进行短期随访。方法选取我院2015年3月〜2017年1月收治的120例EBV阳性弥漫大B细胞淋巴瘤患者为本次研究对象,按照治疗方式不同分为对照组(60例,CHOP方案)与观察组(60例,美罗华+CHOP方案),对比两组疗效、生存率、无进展生存率、不良反应。结果观察组临床治疗总有效率为91.67%(55/60),远高于对照组的75.00%
2、(45/60),数据组间对比差异有统计学意义(P<0.05)。观察组生存率96.67%(58/60),对照组生存率91.67%(55/60),数据组间对比差异无统计学意义(P>0.05);观察组无进展生存率60.00%(36/60),对照组无进展生存率41.67%(25/60),数据组间对比差异有统计学意义(P<0.05)。观察组在治疗过程中未出现恶心呕吐、发热毒副反应,与对照组对比,差异有统计学意义(P<0.05),其余壽副反应数据组间对比差异无统计学意义(P>0.05)o结论美罗华+CHOP方案治疗EBV阳性DLBCL患者能够有效提升其临床效果与无进展生存率,且降低恶心呕吐、发热毒副
3、反应,其余毒副反应与CHOP方案无明显差异,可临床应用与推广。[关键词]美罗华;弥漫大B细胞;淋巴瘤;化学治疗[中图分类号]R733.4[文献标识码]A[文章编1673-9701(2018)05-0013-04[Abstract]ObjectiveToevaluatetheefficacyofrituximabcombinedwithCHOPregimen(cyclophosphamide+epirubicin+vincristine+prednisone)inthetreatmentofEBV-positivediffuselargeB-celllymphomaandtoconduct
4、short-termfollow-up.Methods120patientswithEBV-positivediffuselargeBcelllymphomawhoweretreatedinourhospitalfromMarch2015toJanuary2017wereselectedasthestudysubjectsanddividedintocontrolgroup(n二60,CHOPregimen)andobservationgroup(n=60,rituximab+CHOPregimen),accordingtodifferenttreatmentmethods.Thecur
5、ativeeffect,survivalrate,progress!on-freesurvivalrateandadversereactionswerecomparedbetweenthetwogroups.ResultsThetotaleffectiverateofclinicaltreatmentinobservationgroupwas91.67%(55/60),whichwasmuchhigherthanthatincontrolgroup(75.00%,45/60).Therewassignificantdiffereneebetweentwogroups(P<0.05).Th
6、esurvivalrateoftheobservationgroupandthecontrolgroupwas96.67%(58/60)and91.67%(55/60),respectively,andtherewasnosignificantdiffereneeinthedatabetweenthetwogroups(P>0.05)・Theprogressive-freesurvivalratewas60.00%(36/60)intheobservationgroupand41.67%(25/60)inthecontrolgroup,andthediffereneewassignifi
7、cantbetweenthetwogroups(P<0.05)・Adversereactions:Thenauseaandvomiting,fevertoxicdidnotoccurintheobservationgroupinthecourseoftreatment,andtherewassignificantdiffereneeinthecorrespondingdatasetsbetweentheobservationgrou