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1、牙周治疗对冠心病伴牙周炎患者血清HsCRP、TNF—a、IL—1P、IL—6水平的影响【摘要】目的:探讨牙周治疗对冠心病伴牙周炎患者血清HsCRP、TNF-a,IL-13,IL_6水平的影响。方法:选取2012年6月-2013年6月期间本院收治的95例冠心病伴牙周炎患者,均进行牙周综合干预,比较干预前与干预6个月后血清TNF-a,HsCRP、IL-6.IL-10水平的变化及(牙周炎)附着水平改善的相关性。结果:治疗后患者血清TNF-a,HsCRP、IL-6,IL-13水平均较治疗前显著降低,差异均有统计学意义(P〈0.01);患者血
2、清TNF-a,HsCRP、IL-6,IL-13水平与(牙周炎)附着水平呈负相关,差异均有统计学意义(P<0.05)o结论:牙周治疗可有效降低冠心病伴牙周炎患者血清HsCRP、TNF-a,IL-1P、IL-6水平,且患者血清TNF-a.HsCRP、IL-6.IL-1{3水平与(牙周炎)附着水平呈负相关,可在一定程度上预测患者牙周炎改善程度。【关键词】牙周治疗;冠心病伴牙周炎;HsCRP;TNF-a;IL-13[Abstract]Objective:Toinvestigatetheeffectofperiodontaltherapyon
3、serumHsCRP,TNF-a,IL-1,IL-6levelofcoronaryheartdiseasepatientswithperiodontitis.Method:95coronaryheartdiseasepatientswithperiodontitiswereselectedfromJune2012toJune2013inourhospitalduringtheperiod,allpatientsweregivenperiodontalintervention.TheserumTNF-a,HsCRP,IL~6,IL-1
4、Plevelchangesand(periodontitis)attachmentlevelimprovedcorrelationwerecomparedbeforetheinterventionand6monthsafterintervention.Result:Aftertreatment,theserumTNF-a,HsCRP,IL_6,IL~13levelsweredecreasedsignificantly,thedifferenceswerestatisticallysignificant(P<0.01),theseru
5、mTNF-a,HsCRP,IL-6,IL~13levelswerenegativelycorrelatedwith(periodontitis)attachmentlevel,thedifferenceswerestatisticallysignificant(P<0.05).Conclusion:TheperiodontaltreatmentcaneffectivelyreduceserumHsCRP,TNF-a,IL~1,IL~6levelofcoronaryheartdiseasepatientswithperiodontit
6、is,andserumTNF-a,HsCRP,IL-6,IL-1Plevelsarenegativelycorrelatedwith(periodontitis)attachmentlevel,andtosomeextentcanpredictthedegreeofimprovementinpatientswithperiodontitis.【Keywords】Periodontaltreatment;Coronaryheartdiseasepatientswithperiodontitis;HsCRP;TNF-a;IL-13Fir
7、st-authorsaddress:TheThirdVeteransHospitalofGuangdongProvince,Guangzhou506157,Chinadoi:10.3969/j.issn.1674-4985.2014.22.021随着我国经济、社会的发展,饮食结构、生活方式的转变,人口的老龄化,心脑血管病的发病率不断上升[1]。在中老年人群中,冠心病在患者死因中占据第一位[2]。炎症和感染过程参与了动脉粥样硬化及其并发症的发生和发展,与患者心脑血管疾病的发生密切相关[3]。已有研究显示,牙周炎与冠心病相关,尤其是CR
8、P已被公认为是心血管疾病事件强有力的、独立危险因素,牙周炎患者患冠心病的相对风险高于非牙周炎患者[4]。目前国内外关于牙周治疗对冠心病伴牙周炎患者血清HsCRP、TNF-a、IL-13.IL-6水平的影响研究报道甚少。本研究分析牙周治