PCI对冠心病患者血清hsCRP、IL6、oxLDL的影响

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1、PCI对冠心病患者血清hs-CRP、IL-6、ox-LDL的影响【摘要】目的：观察PCI对冠心病患者血IL-6、hs-CRP、ox-LDL的影响，探讨IL-6、hs-CRP、ox-LDL与冠脉病变程度的相关性。方法：对94例冠心病患者行冠状动脉造影(SCAG)，按SCAG结果分为PCI组67例和对照组27例，两组均于术前及术后4小时取肘静脉血，测定血清hs-CRP、IL-6及ox-LDL水平。结果：与术前比较，PCI组术后血清hs-CRP水平显著增高(P<0.05)，IL-6、ox-LDL水平差异无统计学意义(P>0.05);与对照组比较

2、，PCI组术前、术后血清hs-CRP、IL-6、ox-LDL水平差异均有统计学意义(P<0.05)。多支及双支病变组术前和术后血清hs-CRP水平显著高于单支病变组(P<0.05);多支病变组术前和术后IL-6水平显著性高于双支和单支病变组(P<0.05);三组间ox-LDL水平差异无统计学意义(P>0.05)。弥漫病变组和长病变组血清hs-CRP、IL-6水平明显高于局限病变组，差异有统计学意义(P<0.05);血清ox-LDL水平各组间比较，差异无统计学意义(P>0.05)。结论：炎症因子与ox-LDL对CHD

3、的诊断、危险性预测具有临床价值。CHD患者血清IL-6、hs-CRP水平与冠脉病变程度存在相关性。【关键词】冠心病PCIIL-6hs-CRPox-LDL　AbstractObjective:Toobservetheeffectofpercutaneous7coronaryinternvention(PCI)ontheserumlevelsofhs-CRP,IL-6andox-LDLinpatientswithcoronaryheartdisease(CHD)andtoanalyzetherelationshipbetweentheirlevelsan

4、dtheseverityofCHD.　　Methods:Selectivecoronaryangiographywasperformedin94CHDpatients.AngiographicimagesshowedthatCHDpatientswithone-vessel,two-vessel,andmulti-vesselstenosisandshowedlong,diffuse,andlocallesions.ThepatientsweredividedintoPCIgroup(67patients)andcontrolgroup(27pati

5、ents)bydifferentangiographicresults.Bloodsampleswereharvestedin4hoursaftertreatmentandserumhs-CRP,IL-6andox-LDLlevelsweremeasured.Results:Comparedtothosebeforetreatment,hs-CRPwassignificantlyincreasedinthePCIgroup(P<0.05),whileIL-6andox-LDLdidnotdiffer(P>0.05);comparedtot

6、hoseinthecontrolgroup,hs-CRP,IL-6,andox-LDLweremarkedlydifferentbothbeforeandaftertreatment(P<0.05).Bothbeforeandaftertreatment,CHDpatientswithtwo-andmulti-vesselstenosishadhigherhs-CRPlevelthanthosewithone-vesseldid(P<0.05);thosewithmulti-vesselstenosishadhigherIL-6level

7、thanthosewithone-ortwo-vesselstenosis(P<0.05);nodifferencewasnotedinox-LDLlevelamongthe3groups.CHDpatientswithdiffuseandlonglesionshadincreasedhs-CRPand7IL-6ascomparedtothosewithlocallesions(P<0.05);ox-LDLdidnotdifferamongthe3groups(P>0.05).Conclusion:PCImaybeeffective

8、toimprovethelevelsofhs-CRP,IL-6andox-LDLandthesefactor