gq蛋白及rgs在急性呼吸窘迫综合征中的作用机制分析

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1、第三军医大学博士学位论文常用英文缩略词表缩写英文全称中文译名ACAdenylatecyclase腺苷酸环化酶ALIAcutelunginjury急性肺损伤ARDSAcuterespiratorydistresssyndrome急性呼吸窘迫综合征AsODNAntisenseoligodeoxynucleotide反义寡核苷酸DABDiaminobezidine二氨基联苯胺DEPCDiethylpyrocarbonate焦碳酸二乙酯DTTDithiothreitol二硫苏糖醇dNTPDeoxyribonucleictriphosphate脱氧核苷三磷酸EDTAE

2、thylenediaminetetraacetieacid乙二胺四乙酸ETEndothelin内皮素IP3Inositol·1，4，5-trisphosphatel，4，5-三磷酸肌醇LBILun：g／bodyweightindex肺体指数mRNAMessengerRNA信使RNANF—v．BNuclearfactorrJ3核转录因子KBP峨plateletactivatingfactor血小板活化因子PLCPhospholipaseC磷酯酶CPMSFPhenylmethylsulfonylfluoride苯甲基磺酰氟RGSRegulatorofGprote

3、insignalingG蛋白信号转导调节因子RLWRateoflungwater肺含水率TXA2ThromboxaneA2血栓素A2第三军医大学博士学位论文ThemechanismofGqproteinandRGSonARDSAbstractAcuterespiratorydistresssyndrome(ARDS)isoneofthediseasesthatisseverelyharmfultohuman’Shealth．Althoughthedeath-rateofARDShasbeendecreasedinrecentyears．itisstillad

4、ifficultpointinclinictherapy．Thelungdamagemaybecausedbydirectinjuryoflungsubstance；ormassinflammatorymediatorsreleasedafteracuteinflammatoryreaction，whichcancauseexaggeratedoruncontralledinflammatoryresponse．nleExaggeratedoruncontralledinflammatoryresponseisoneofthemainreasonoflung

5、injury．Uptodate，themostdirectsignalofactivationofexaggeratedoruncontralledinflammatoryresponseiSstillunclear．ButitisshownthatGqprotein—coupledreceptors(suchasTXA2、PAF、ETreceptors、playimportantrolesintheprocessofacutelunginjury．Thesereceptorshaveimportantroleinplateletaggregation§br

6、onchospasmandendovascularmicrothrombosis．EachoftheseGqprotein-coupledreceptorantagonistcouldpartlydecreaselungedema．Ofcause，manyknownorunknowncytokinesalsohaverolesinARDSpathogenesis，butwhichisthemostimportantoneisstillhardtoanswer．Althoughcytokinesandchemokineshavealargenumberofme

7、mbers，signalpathwaysarefewer，andGproteinsignalpathwayisoneofthemostimportantpathwayswhichregulatenumerouscytokinesandchemokinestheireffects．Gqproteincoupledreceptorstakepartinthepathophysiologyofacutelunginjury，SOregulationofGqanditspathwaymaybehavesignificantroleinthisprocesss．New

8、lydiscoveredregulatorofG-p