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1、复发性外阴阴道假丝酵母菌病菌种与药敏特征的研究【摘要】目的:了解假丝酵母菌在复发性外阴阴道假丝酵母菌病的菌种分布和药物敏感性，为临床治疗提供帮助。方法：收集108例复发性外阴阴道假丝酵母菌病阴道分泌物标本，应用法国生物梅里埃酵母菌鉴定试剂盒ID32C和药敏试剂盒ATBTMFUNGUS3进行鉴定和药敏试验。结果：208株假丝酵母菌中分离出光滑假丝酵母菌36例，白色假丝酵母菌35例，近平滑假丝酵母菌20例，热带假丝酵母菌7例，其他11例;对抗真菌药物AMB、5FC敏感性分别为96.30%、85.19%,对FCA、VRC、ITR耐药率分别为
2、42.59%、50.93%、72.22%0有26株白色假丝酵母菌对3种三哇类药物均耐药。光滑假丝酵母菌对ITR耐药率高达83.33%o结论：复发性外阴阴道假丝酵母菌病的致病菌主要是光滑假丝酵母菌、白色假丝酵母菌，呈现非白假丝酵母菌占67.59%的分布特征，并且对AMB、5FC敏感性高，ITR耐药率高于VRC、FCAo【关键词】假丝酵母菌病；菌种；敏感性；耐药StrainsanddrugsusceptibilityofvaginalcandidainrecurrentvulvovaginalcandidiasisCHIShaoqin?l
3、,WANGYuehong?l,XIEDielan?21FamilyPlanningServiceCentreofLonggangdistrict,GuangdongShenzhen518172,China2TheCentralHospitalofLonggangDistrict,GuangdongShenzhen518172,China[Abstract]Objectives:Toinvestigatecandidastrainsanddrugsusceptibilityofthevaginalcandidainrecurrentvu
4、lvovaginalcandidiasis(RVVC),andtoprovidereferencetoclinicaltreatment.Methods:Thesamplesfrom108patientswithrecurrentvulvovaginalcandidiasiswerecollectedandtheirvaginalsecretionaremeasuredwithbioMerieuxkitofID32CforcandidastrainsandwithATBTMFUNGUS3kitfordrugsusceptibility
5、test.Results:Among108casesofCandidathereare36Candidaglabratacases,35Candidaalbicanscases,20Candidaparapsilosiscases,7tropicaliscases,and11otherCandidascases・ThesensitivitiestoAMBand5FC,twokindsofantifungaldrugs,are96.30%and85.19%respective!y.DrugresistaneeratestoFCA,VRC
6、andITR,are42.59%,50.93%and72.22%respective!y.Therewere26Candidaalbicansresistanttoallthreetriazoles.Thedrugresistancerateisupto83.33%forCandidaglabrata.Conclusions:CandidaglabrataandCandidaalbicanswerethemainpathogenicfungiforrecurrentvulvovaginalCandidiasis.Thenon-Cand
7、idaalbicanstakesup67.59%candidaspecies,andtheyaresensitivetoAMBand5FC.ThestrainsshowahigherdrugresistaneeratetoITRthantoVRCandFCA.[Keywords】Candidiasis;Strains;Susceptibility;Resistanee外阴阴道假丝酵母菌病(vulvovaginalcandidiasisyvO是常见外阴阴道炎症，也称外阴阴道念珠菌病。临床症状主要表现为外阴瘙痒、灼痛，严重时坐卧不宁，异常
8、痛苦，还可伴有尿痛及性交痛⑴。复发性外阴阴道假丝酵母菌病(Recurrentvulvovaginalcandidiasis,RVVC)因其1年内发作4次或以上，严重影响育龄妇女的身心健康，成为生殖道感染治疗的顽症，引起国
