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1、不同浓度异丙酚持续输注对家兔脂代谢的影响姓名：2014年6月25日不同浓度异丙酚持续输注对家兔脂代谢的影响作者：周FM华，徐礼鲜，张惠，李源，徐瑞芬，王惠®,刘春然【关键词】浓度Effectofcontinuouslyinfusedpropofolofdifferentconcentrationsonserumlipidmetabolisminrabbits【Abstract】AIM:Toobservethepharmacodynamicsof50g/Lpropofolanditseffectontheserumlipidmetabolismo
2、frabbits.METHODS:Twelverabbitsofbothsexeswererandomizedinto2groups.Allrabbitsreceived6mg/kgbolusdosesataspeedof0.6mg/sof10g/Land50g/Lpropofolfromamarginalearvein，theeffectonsettimewasrecorded.Propofolwasthenadministeredundercomputercontrolfor360minataspeedof400(ig/(kgmin).Th
3、eheartrate,bloodpressureandrespirationrateweremeasuredduringtheinfusion,andtherecoverytimewasrecorded.Arterialbloodsampleswerecollectedbeforeinfusionand5,30,60，180,360and365minafterinfusionforthemeasurementofbloodpropofolconcentrationsandtheserumconcentrationsoftriglyceride，
4、cholesterol，highdensitylipoproteincholesterolandlowdensitylipoproteincholesterol.RESULTS:Theeffectonsettimeandthebloodpropofolconcentrationsatdifferenttimepointshadnostatisticaldifference(P0.05).Inthe10g/Lpropofolgroup，comparedwithpreinfusion,theserumtriglyceridelevelsweresi
5、gnificantlyincreased60，180and360minafterinfusion(P0.01)，andtheserumcholesterolconcentrationwasalsoelevated360minafterinfusion(P0.01).Inthe50g/Lpropofolgroup,theserumtriglyceridelevelwasstatisticallyhigheronlyafter360mininfusion(P0.01)thanthatbeforeinfusion,butwassignificantl
6、ydecreasedwhencomparedwiththatofthe10g/Lpropofolgroupatthesametime.Therewasnosignificantdifferenceintherecoverytimebetweenthe2groups(P0.05).CONCLUSION:50g/Lpropofolhasthepharmacodynamiceffectsimilartothatof10g/Lpropofol,buttheformercandelaytheoccurrenceofserumlipidmetabolism
7、.【Keywords】propofol；serumlipid；anesthesia【摘要】目的：观察50g/L异丙酚的药效及对家兔脂代谢的影响.方法:选择家兔12只，随机分为10g/L，50g/L异丙酚组，每组6只.10g/L,50g/L异丙酚单次首次剂量为6mg/kg,以0.6mg/s从家兔耳缘静脉分别匀速注射，记录起效时间.注射完毕后接麻醉注射泵以400pig/（kgmin）的速度持续输注异丙酚360min,记录心率、血压和呼吸等生命体征变化及停药后苏醒时间.并于注射前、注射完毕、持续输注后5,30,60,180,360和365min分别抽
8、血样，检测血浆药物浓度，及血清甘汕三酯（TG）,总胆固醇（TC）,高密度脂蛋白胆固醇（HDLc）,低密度脂蛋白胆固醇（LDLc）的浓度.结果：单次静脉
