液体活检在胶质瘤研究中的概况

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1、授予单位代码10089学号或申请号20153276中国图书分类号R739.4HebeiMedicalUniversity硕士学位论文专业学位液体活检在胶质瘤研究中的概况研究生：王曼导师：扈玉华教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要···········································································································1英文摘要·············

2、·····························································································2英文缩写··········································································································3综述液体活检在胶质瘤研究中的概况····································

3、·····················5致谢·················································································································23个人简历·········································································································24中文摘要液体活

4、检在胶质瘤研究中的概况摘要目的：简述液体活检技术及在胶质瘤研究中的概况，以便进一步指导胶质瘤的诊断、治疗和预后评估。内容：液体活检是近几年新兴起来的癌症检测方法，其快速、简便、创伤性小、可重复性好，发展势头旺盛。胶质瘤是最常见的颅内原发恶性脑瘤，恶性程度极高。即使应用目前指南规定的标准化治疗，患者仍然面临肿瘤复发甚至死亡。查阅近几年国内外的期刊杂志及治疗指南，归纳了液体活检的几种技术及其在胶质瘤诊断、治疗、预后及复发监测中的应用概况及新方向，包括循环肿瘤细胞、循环肿瘤DNA及外泌体的来源、生物学特性及在胶质瘤

5、研究中的应用等。方法及结果：通过万方数据知识服务平台、中国知网、Pubmed等网络资源查找近几年国内外的期刊杂志及治疗指南，仔细研读、翻译。结论：液体活检在胶质瘤中巨大的临床应用前景不容忽视，必将成为肿瘤领域精准医学的重要组成部分，我们要继续寻找更好的富集与检测技术。关键词：液体活检，胶质瘤，循环肿瘤细胞，循环肿瘤DNA，外泌体、1英文摘要ThegeneralsituationofliquidbiopsyinthestudyofgliomaABSTRACTObjective:Introductionofthe

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