血浆scd-40l对于不同类型冠心病患者的临床意义

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1、授予单位代码10089学号或申请号16158中国图书分类号R541.4HebeiMedicalUniversity硕士学位论文学术学位血浆sCD40L对于不同类型冠心病患者的临床意义研究生刘丹亮导师姜云发教授专业内科学二级学院第二医院2018年3月目录中文摘要·································································································10英文摘要··················

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6、················19综述CD40L系统在急性冠脉综合症的研究进展····································25致谢·································································································44个人简历····································································

7、·····························45血浆sCD40L对于不同类型冠心病患者的临床意义摘要目的：本课题观察血浆可溶性CD40L(sCD40L)水平在不同类型冠心病(CHD)患者的变化，探讨其与冠脉狭窄程度之间的关系，以及与急性冠脉综合症(ACS)患者TIMI危险积分间的相关关系。方法：本研究选择急性心肌梗死(AMI)30例，不稳定型心绞痛(UA)30例，稳定型心绞痛(SA)30例，对照组30例进行对比研究。入院后于发病24h内抽取静脉血。采用酶联免疫吸附分析法(ELISA法

8、)检测sCD40L浓度。比较各组间sCD40L含量有无差异，并将AMI组中非ST段抬高心肌梗死组（NSTEMI）及UA组的sCD40L含量与TIMI危险积分进行比较。CHD各组sCD40L含量与冠脉造影Gensini积分进行相关性分析。结果：UA组、AMI组sCD40L水平明显高于对照组和SA组(P<0.05)，而UA组与AMI组无显著差异。NSTEMI组及UA组按TIMI危险积分分为≥3分组(n=23)和≤2分组(n=20)，其中≥3分组sCD40L水平明显高于≤2分组(P<0.