冠心病患者血浆ykl-40水平升高的临床意义

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1、广州医学院硕士学位论文冠心病患者血浆YKL-40水平升高的临床意义ClinicalsignificanceoftheelevatedplasmaYKL-·40LevelsinPatientswithCoronaryHeartDisease[Background]ABSTRACTAtherosclerosisiSconsideredtObeacllromcinflammatorydiseasecharacterizedbyendothelialdysfunctionandextracellulartissueremodeling．Ithasbecomeincreasinglyclearthati

2、nflammationplaysanimportantpartintheinitiationanddevelopmentofcoronaryheartdisease(CHD)．Humancartilageglycoprotein-39(YKL·40)isanewinflammatorymarkerwhichisinvolvedinremodelingandangiogenesisofnon-cardiacinflammatorydiseases．RecentstudiesshowedthatYKL一40Wasabundantlysecretedbylipid-ladenmacrophagesi

3、nsidehumanatheroscleroticvesselwall．However,therelationshipbetweenCHDandhumanplasmaYKL·40levelremainsunknown．【Objectives]TheaimofthisstudyWastOmeasuretheYKL一40levelsandhs。CRPlevelsofCHDpatients，evaluatetheseverityofarterystenosisbyCAGandGensiniScore，investigatetheassociationofplasmaYKL-40levelsandhs

4、—CRPlevelswiththeseverityofCHDandthearterystenosisextent．discusstherelationshipbetweeninflammatoryinjuryandplaquestability,analyzehowYKL·40asanewinflammatorymarkerco．elate、析thhs—CRPandothercardiovascularriskfactors，exploretheclinicalsignificanceofYKL一40measurememintheevaluationandprognosticationofCH

5、Dpatients．[Methods]Atotalof165in·hospitalpatientswhichfromdepartmentofcardiologyofthe5广州医学院硕士学位论文冠心病患者血浆YKL-40水平升高的临床意义SecondaffiliatedHospitalofGuangzhouMedicalCollegeandtheSecondaffiliatedHospitalofSouthemMedicalUniversityZhujiangHospitalduringOct2008toFeb2009wasrecruitedtothisstudy．Allsubjectswer

6、eevaluatedbyCAGallthecaseswereclassifiedasCHDgroup(n=130)andControlgroup(n=35)accordingtotheresultsofCAG．ThediagnosticcriteriaforCHD：atleastonemajorcoronaryarteryoritsbranches≥50％stenosis．TheCHDgroupWasdividedinto2groupsaccordingtOtheseverityofthediseaseandtheplaquestability：Acutecoronarysyndrome(n=

7、101)，StableAnginaPectoris(11_29)．TheCHDgroupwasalsogroupedintosingle-vesselgroup(n．=43)andmulti-lesiongroup(n=87)accordingtothenumberofinvolvedcoronarybranches．BasedonwhetherthepatienthadDiabetes，ther