氯替泼诺联合泪道激光置管术治疗泪道阻塞的疗效研究

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1、授予单位代码10089学号或申请号20153289中国图书分类号R777.2HebeiMedicalUniversity硕士学位论文专业学位氯替泼诺联合泪道激光置管术治疗泪道阻塞的疗效研究研究生：高欣导师：任彦新教授专业：眼科学二级学院：河北医科大学第二医院2018年3月目录中文摘要·······································································································1英文摘要·····················

2、··················································································2研究论文氯替泼诺联合泪道激光置管术治疗泪道阻塞的疗效研究前言·······································································································5材料与方法·················································

3、··········································6结果·······································································································9附表·······································································································11讨论·············

4、··························································································14结论·······································································································18参考文献····································································

5、························18综述泪道阻塞性疾病的治疗进展··························································21致谢·······································································································36个人简历····························································

6、···········································37中文摘要氯替泼诺联合泪道激光置管术治疗泪道阻塞的疗效研究摘要目的：探讨氯替泼诺混悬滴眼液(LoteprednolEtabonateOphthalmicSuspensionLEOS)的应用对激光联合泪道置管术治疗泪道阻塞的临床疗效。方法：收集泪道阻塞(泪小管和泪总管阻塞)患者共72例(101眼)，行泪道激光联合置管术，术中测量泪道阻塞的长度，并分为2组：对照组：30例(39眼)，其中阻塞长度≥4mm的16只眼，术后给予左氧氟沙星滴眼液；实验组：42例

7、(62眼)，阻塞长度≥4mm的21只眼，术后给予左氧氟沙星滴眼液和氯替泼诺混悬滴眼液。两组均术后3个月取出泪道引流管。术后1个月、3个月、取管后1个月、3个月，观察患者有无溢泪症状，冲泪道是否通畅；比较两组术后1个月、3个月、取管后1个月、3个月时的有效率和治愈率，以及阻塞长度对预后的影响。结果:术后1个月和术后3个月时两组的疗效差异无统计学意义。实验组取管后1个月、3个月的总有效率为95.2%、96.8%，对照组取管后1个月、3个月的总有效率为89.7%、84.6%，两组比较差异有统计学意义(P＜0.05)。实验组阻塞长度≥4mm的总

8、有效率90.5%，＜4mm的总有效率100%。两组资料比较有统计学意义(χ2=7.593,P＜0.05)。对照组阻塞长度≥4mm的总有效率66.8%，＜4mm的总有效率95.7%。两组相比有统计学意义(χ2