心脉隆治疗冠脉三支病变合并心衰的临床研究

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1、心脉隆治疗冠脉三支病变合并心衰的临床研究梁田张庆(江苏省徐州市中医院心内科江苏徐州221003)【摘要】目的：探讨心脉隆注射液治疗冠脉三支病变合并心袞(CHF)患者的疗效及安全性。方法：将冠脉造影三支病变合并心衰的住院64例患者〔纽约心脏病协会(NYHA)心功能分级III〜IV级)随机分为治疗组32例和对照组32例，两组均按照《慢性心功能袞竭诊断治疗指南》进行治疗，对照组使用利尿剂、血管紧张素转换酶抑制剂(ACEI)及酌情使用硝酸脂类、洋地黄类药物，治疗组在此基础上加用心脉隆注射液8ml+5%葡萄糖注射液或0.9%氯化钠溶液100ml静脉滴注，2次/天，连用

2、14天。比较两组治疗后的临床效果、左心室射血分数(LVEF)和B型脑钠(BNP)的变化。结果：对照组显效4例、有效14例、无效14例，治疗组显效8例、有效19例、无效5例，两组治疗效果间差异有统计学意义(P<0.05)。治疗后治疗组LVEF高于对照组，BNP水平低于对照组，差异均有统计学意义(P<0.05>。两组不良反应发生率比较，差异无统计学意义(P〉0.05>。结论:心脉隆注射液可降低冠脉三支病变患者心脏负荷，抑制神经内分泌激活，改善心功能。【关键词】冠心病；三支病变；慢性心力衰竭；心脉隆注射液；心功能【中图分类号】R54【文献标识码】A【文章编号】20

3、95-1752(2015)32-0069-03ClinicalEffectofXinmailongInjectionintheTreatmentofHeartFailureamongTriplevesselcoronaryheartdiseaseLiangTian,ZhangQing.DepartmentofCardiology,XuzhouCityHospitalofTraditionalChineseMedicine,Xuzhou221009,Jiangsu,China【Abstract】ObjectiveToinvestigatethecurative

4、effectandsafetyofXinmailonginjectionintreatingchronicheartfailure(CHF)amongtriplevesselcoronaryheartdisease.Methods64triplevesselcoronaryheartdiseasecombinedCHFpatientswithcardiacfunctionalgradingfromtoweredividedintotreatmentgroup(32cases)andcontrolgroup(32cases).Thetwogroupsweret

5、reatedaccordingtoCHFtreatmentguide.ThecontrolgroupwasgivendiureticangiotensinconvertingenzymeinhibitorandappropriatelevelsofnitricacidlipideanddigitaloiddrugswhilethetreatmentgroupwasgivenadditionalintravenousdripofXinmailonginjectionand100ml5percentglucoseinjectionor0.9percentsodi

6、umchloridesolutiononetimedailyfor14consecutivedays.Thechangesofclinicaleffectleftventricularejectionfraction(LVEF)andBNPaftertreatmentwerecomparedbetweenthetwogroups.ResultsInthecontrolgroup4casesweresignificantlyimprovedMeaseswereimprovedandMeaseswereinvalidwhileinthetreatmentgrou

7、p8casesweresignificantlyimproved19caseswereimprovedand5caseswereinvalid.Thedifferencebetweenthetwogroupswasstatisticallysignificant(P<0.05).AftertreatmenttheLVEFoftreatmentgroupwassignificantlyhigherthanthecontrolgroupandtheBNPwassignificantlylowerthanthecontrolgroup(P<0.05).

8、Theadverseeffectrateofthet