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1、探讨高血压肾病早期肾损伤联合检测同型半胱氨酸和胱抑素C的临床价值李丽J*良辰(沾化县人民医院检验科Hl东沾化256800)【摘要】RW:探讨高血压肾病旱期肾损伤联合检测同型半胱氨酸和胱抑素C的临床价值。方法:选择2013年1月至2015年10月诊为高血压肾病的患者92例组成实验组,选择同期健康体检者30例设为对照组,同时测定同型半胱氨酸和胱抑素C的浓度水平,综合分析结果。结果:实验组患者的同型半胱氨酸和胱抑素C浓度水平明显高于对照组,差异具有统计学意义(P<0.05),且随着病程增长,同型半胱氨酸和胱抑素C浓度水平均呈现上升趋势;同
2、型半胱氨酸和胱抑素C的敏感性均超过80.00%,早期组患者联合检测同型半胱氨酸和胱抑素C的敏感性明显高于同期单项检测结果,差异具有统计学意义(P<0.05),特异性有所降低,但屮期组和晚期组无明显差异(P〉0.05).结论:同型半胱氨酸和胱抑素C都是辅助诊断高血压肾病的有效指标,且对于疾病的监测和愈后也有一定价值,联合检测能够有效提高早期肾损伤的敏感性,降低漏诊风险。【关键词】高血压肾病;同型半胱氨酸;胱抑素C【中图分类号】R544.1【文献标识码】A【文章编号】1007-8231(2015)22-0044-02Toexploret
3、heclinicalsignificanceoftheearlyrenaldamageofthehypertensivenephropathydiagnosisbytheHomocysteineandCystatinCjointdeterminationULi,DingLiangchen.TheLaboratoryMedicineoftheZhanhuaPeople’sHospital,Shandong,256800,China【Abstract】ObjectiveToexploretheclinicalsignific
4、anceoftheearlyrenaldamageofthehypertensivenephropathydiagnosisbytheHomocysteineandCystatinCjointdetermination.MethodsChoosing92casesofpatientswiththehypertensivenephropathyfortheexperimentalgroupand30caseshealthycheck-upforthecontrolgroup,testingtheplasmaHomocysteinean
5、dtheCystatinC,analyzetheresultscomprehensively.ResultsThereweresignificantmuchHigheroftheHomocysteineandtheCystatinCoftheexperimentalgroupthanthecontrolgroup(P<0.05),andwiththecourseofgrowth,homocysteineandcystatinClevelsshowedarisingtrend.ThepositiverateoftheHomocyste
6、ineandtheCystatinCweremorethan80%,thereweresignificantmuchHigheroftheHomocysteineandtheCystatinCjointdeterminationoftheearlygroupthanSeparatedetection(P〉0.05),thespecificitydecreased,buttherewerenosignificantdifferencesofthemetaphasegroupandadvancedgroup.ConclusionTher
7、ebothareeffectiveindexesoftheHomocysteineandtheCystatinCforthehypertensivenephropathydiagnosis,andthereisacertainvalueforthemonitoringofthediseaseandthehealingofthedisease,andjointdetectioncanimprovethesensitivityofearlykidneydamageandreducetheprobabilityofmisseddiagno
8、sis.【Keywords】Hypertensivenephropathy;Homocysteine;CystatinC肾脏是人体重要器官,不但对于调节血压起重要作用,也是重要的高血压相关损害靶器官之一。高血压肾病是临床常见的高血压并