脑出血微创置管吸引术对老年脑出血患者血清il―6、tnf―α和hs―crp的影响分析

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1、脑出血微创置管吸引术对老年脑出血患者ifc清IL—6、TNF-a和hs—CRP的影响分析［摘要］目的探讨脑出血微创置管吸引术对老年脑出血患者血清IL-6、TNF-a和hs_CRP的影响。方法选取本院2011年5月〜2013年5月收治的64例老年脑出血患者作为研究对象，随机分为对照组和观察组，各32例。对照组给予常规药物保守治疗，观察组在对照组的基础上行钻孔置管血肿抽吸液化引流术，比较两组术后2、7、15和30d的IL-6、TNF-a和hs_CRP水平。结果观察组术后7、15d的血清IL-6、TNF-a和hs_CRP水平显著低于对照组，差异有统计学意义(P0.05)。结

2、论脑出血微创置管吸引术治疗老年脑出血效果显著，能降低血清炎性因子水平，防止炎性介质损伤脑组织，值得临床推广应用。［关键词］脑出血微创置管吸引术；老年；脑出血；血清炎性因子分类号］R743.34［文献标识码］A［文章编号］1674-4721(2015)06(a)-0061-03InfluenceanalysisofcerebralhemorrhageminimallyinvasivecatheteraspirationforserumIL-6,TNF-ctandhs-CRPinelderlypatientswithcerebralhemorrhageXIAOWei-1i

3、YUANShao-pengHUJian-junDepartmentofNeurosurgery,PeoplezsHospitalofSanshuiDistrictofFoshanCityinGuangdongProvince,Foshan528100,China[Abstract]ObjectiveToexploretheinfluenceofcerebralhemorrhageminimallyinvasivecatheteraspirationforserumIL-6,TNF-ctandhs~CRPinelderlypatientswithcerebralhemo

4、rrhage.Methods64caseswithcerebralhemorrhageinourhospitalfromMay2011toMay2013wereselectedandrandomlydividedintothecontrolgroupandtheobservationgroup,32casesineachgroup.Thecontrolgroupwastreatedwithconventionalconservativetreatment,theobservationgroupwastreatedwithhematomaaspirationandliq

5、uefactionfordrillingcatheteronthebasisofthecontrolgroup.ThelevelofIL_6,TNF-aandhs~CRPinpostoperative2,7，15，30dintwogroupswascompared.ResultsThelevelofserumIL-6,TNF-aandhs~CRPinpostoperative7，15dofobservationgroupwaslowerthanthatofthecontrolgroup,withsignificantdifference(P0.05).Conclusi

6、onTheapplicationeffectofcerebralhemorrhageminimallyinvasivecatheteraspirationinthetreatmentofelderlypatientswithcerebralhemorrhageissignificant,whichcanreduceserumlevelsofinflammatorycytokines,preventdamagetobraintissue,itisworthyofclinicalpromotionandapplication.［Keywords］Cerebralhemor

7、rhageminimallyinvasivecatheteraspiration；Theelderly；Cerebralhemorrhage；Seruminflammatoryfactor老年脑出血是严重危害人类健康的脑血管疾病，具有高发病率、高致残率和高致死率等特点［1］。临床治疗老年脑出血的难度较大，单纯内科保守治疗周期长，疗效不尽满意，患者死亡率高［2］。高血压性脑出血是临床神经外科的常见病、多发病，其中基底节出血最常见，约占60%,大多是由于各种因素引起血压骤升，导致颅内动脉破裂形成血肿，产生占位效应，并且随着时间的推进，脑组织水肿将进一步加