比伐卢定与替罗非班联合肝素在老年stemi急诊pci治疗中的疗效及安全性比较

《比伐卢定与替罗非班联合肝素在老年stemi急诊pci治疗中的疗效及安全性比较》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、比伐卢定与替罗非班联合肝素在老年STEMI急诊PCI治疗中的疗效及安全性比较泰达国际心血管病医院300457【摘要】目的探讨比伐卢定与替罗非班联合肝素在老年急性ST段抬高型心肌梗死(STEMI)急诊经皮冠状动脉介入术(PCI)屮治疗效果。方法选取2015年10月〜2013年3月我院收治STEMI行急诊PCI的老年患者60例为研宂对象，采用随机分组表将患者随机分为研究组和对照组，研究组患者给予比伐卢定辅助治疗，对照组给予替罗非班联合肝素辅助治疗，比较两组患者术后罪犯血管(TIMI)血流分级、2h心电图ST段回落和治疗30d内心血管事件发生率、出血并发症发生率。结果两组患者

2、TIMI分级屮各级比较无明显差异，无统计学意义(P〉0.05)。两组患者2h心电图ST段回落率、心血管不良事件发生率比较无统计学意义(P>0.05)；治疗30d内研宂组患者出血发生率3.33%显著低于对照组20.00%，t匕较有统计学意义(P<0.05)。结论比伐卢定与替罗非班联合肝素在老年STEMI急诊PCI术屮应用可辅助提高患者临床疗效，但替罗非班联合肝素易增加患者出血风险，比伐卢定具有更高用药安全性。【关键词】急性ST段抬高型心肌梗死；经皮冠状动脉介入术；比伐卢定；替罗非班；肝素【屮图分类号】R148.2【文献标识码】A【文章编号】1001-5213(2016)0

3、8-0344-02[Abstract]ObjectiveToinvestigatethanLucuttingsetandtirofibannonclasscombinedwithheparininelderlypatientswithacuteSTsegmentelevationmyocardialinfarction(STEMI)inemergencypercutaneouscoronaryintervention(PCI)intherapeuticeffect.Methodsatotalof2015February20163monthsinourhospitalST

4、EMIadmittedtoemergencyPCIinelderlypatients80casesastheobjectofstudy,usingrandomizationtablewererandomlydividedintostudygroupandcontrolgroup,patientsinstudygroupweregiventhanbivalirudinadjuvanttherapy,thecontrolgroupwasgiventirofibanclasscombinedwithheparininadjuvanttreatmentandwerecompar

5、edbetweenthetwogroupsofpatientsaftermyocardialinfarctionthrombolytictherapyclinicaltrial(TIMI)And2hofSTsegmentdeclineandtheincidenceofbleeding.ResultsinthetwogroupsofpatientswithTIMIgradeatalllevelshadnosignificantdifference,nostatisticalsignificance(P>0.05).Twogroupsofpatientswith2HE

6、CGSTsegmentresolutionrate,therewasnosignificantdifference(P>0.05);StudyGroupofpatientswithpostpartumhemorrhagerateof2.50%,significantlylowerthanthatofthecontrolgroup17.50%,comparedwithstatisticalsignificance(P<0.05).Conclusioncomparedwithbivalirudinwithtirofibanclasscombinedwithhep

7、arinintheelderlyduringemergencyPCIinpatientswithSTEMIapplicationcanbeassistedtoimprovetheclinicalefficacy,butfornonLuoclasscombinedwithheparinmayincreasetheriskofbleedinginpatientswith,comparedwiththecutLuDinghasahigherdrugsafety.[Keywords]acuteSTsegmentelevationmyocardia