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1、1细胞因子的定义和分类2细胞因子的共同特征和生物学功能。CytokineandcytokinereceptorsChapterIIIHistoryfortheresearchofthecytokinesIn1974,denominatedcytokinecytokinology;internationalcytokinesociety《Cytokine》CompaniesfordevelopingcytokinesinmanycountriesIn1957,Interferon(IFN)wasfoundIn1969,termedlymphokin
2、eMjmacrophageIL-1ActivatedTh1cellaADP56BC58B’CNH2COOHIL-2Cytockinesarelow-molecular-weightregulatoryproteinsorglycoproteinssecretedbywhitebloodcellsandvariouscells(vascularendothelialcell,epidermiccellandfibroblast)inbodyinresponsetoanumberofstimuli.CytokineCytokinegeneInducingstimu
3、lusCytokine-producingcellCytokineGeneactivationReceptorsignalBiologicaleffectsOverviewoftheinductionandfunctionofCytokineSignaltransducersandactivatoroftranscriptionIBiologicaleffectsBiologicaleffectsofthecytokinesAnti-infectionandantitumorImmuneregulationapoptosisStimulatingtheprol
4、iferationanddifferentiationofhemopoieticstemcellsPromotethegrowthanddifferentiationofvariouscellsParticipationandregulationoftheinflammatoryresponsesCytokineabnormalitiesinthepathogenesisincertaindiseasesJustashormonesserveasmessengeroftheendocrinesystem,socytokineseverasmessengerso
5、ftheimmunesystem.Unlikeendocrinehormones,though,whichexerttheireffectsoverlargedistances,cytokinesgeneralactlocally.1.interleukin,IL(白细胞介素)2.colonystimulatingfactor,CSF(集落刺激因子)3.interferon,IFN(干扰素)4.tumornecrosisfactor,TNF(肿瘤坏死因子)5.Chemokine,CK(趋化因子)6.growthfactor,GF(生长因子)IIcytokine
6、sIL-13IL-2IL-41Interleukin,ILInterleukinsaresecretedbysomeleukocytesandactuponotherleukocytes,IL-1~IL-23havebeenidentified.2Colonystimulatingfactor,CSFThecytokinesthatstimulatehemopoieticcellstoformcellcolony,ParticipatehemopoieticfunctionarecalledCSF,forexampleGM-CSF,G-CSF,M-CSF,Ep
7、o,Tpo,G-CSFGM-CSFThefunctionsofCSFThecytokinesthatresistviralinfection,andinterfereviralreplication,includingIFN,IFN(typeI);IFN(typeII)3Interferon,IFNviruscellinfectionIFN-,IFN-IFNIFNTheanti-virusmechanismofIFN-avirusviralreplicationInhibitionofviralreplicationSignal-transduc
8、tionIFN-aIFN-induce