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ID:21068109
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页数:5页
时间:2018-10-19
《埃罗替尼联合gp方案治疗晚期非小细胞肺癌的临床疗效分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、埃罗替尼联合GP方案治疗晚期非小细胞肺癌的临床疗效分张琳琳(辽宁省肿瘤医院内五科辽宁沈阳110042)【摘要】R的:探讨埃罗替尼联合盐酸吉西他滨及顺铂(GP)化疗对晚期非小细胞肺癌的临床疗效。方法:随机抽取采用GP方案化疗的Illb-IV期非小细胞肺癌患者90人,其屮单纯GP方案化疗45人,埃罗替尼联合GP化疗45人。对患者生存率、病情缓解情况和血淸屮VEGF浓度进行观察分析。结果:联合用药组患者病情缓解率达到47.23%,显著高于单纯GP组26.88%(P<0.05)。联合用药组患者一年后生存率达到91.67%,显著高于单纯GP组的81.67%,差异有统计学意义(P<0.05
2、)o联合用药组患者血清屮VEGF浓度为79.8pg/ml,显著低于单纯GP组的124.23pg/ml(P<0.05)o结论:埃罗替尼联合GP化疗较单纯GP方案治疗晚期非小细胞肺癌具有更显著的疗效,可以显著的提高患者的存活率和降低VEGF水平。【关键词】晚期非小细胞肺癌;埃罗替尼;疗效评价;盐酸吉西他滨;顺铂【屮图分类号1R734.2【文献标识码】B【文章编号11003-5028(2015)8-0721-02ClinicalstudyontheefficacyoferlotinibcombinedwithGPchemotherapyintreatmentofadvancednon-sm
3、allcelllungcancer【Abstract】Objective:Toexplorethecurativeeffectoftreatingadvancednon-smallcelllungcancerusingerlotinibincombinationwithgemcitabinehydrochlorideandcisplatin(GP)chemotherapyclinically.Methods:Extracted90patientswhowereintheperiodofIllb-IVnon-smallcelllungcancerandusedGPprogramofchemo
4、therapyrandomly,including45peoplewhousedpureGPchemotherapyand45peoplewhousederlotinibcombinedGPchemotherapy.Recordedthediseaseremission,survivalandserumVEGFlevelchangesofpatientswhowerebeforetreatmentandaftertreatmentrespectively,inordertocomparethecurativeeffectofcombinationwithpureGPpackage.Resu
5、lts:Aftertreatment,rateofremissionofcombinationgroups(47.23%)increasedsignificantlythansimpleGPsolutionsgroup(26.88%)(P<0.05).Whereasoneyearsurvivalrateofcombinationgroups(91.67%)increasedsignificantlythansimpleGPsolutionsgroup(81.67%)(P<O.O5).TheVEGFlevelofcombinationgroups(79.8pg/ml)decrea
6、sedsignificantlythansimpleGPsolutionsgroup(124.23pg/ml)(P<0.05).Conclusion:ErlotinibcombinedwithGPchemotherapyhasamoresignificantcurativeeffectcomparedwithsimpleGPregimeninthetreatmentofadvancednonsmallcelllungcancerandcansignificantlyimprovethepatient’ssurvivalrateanddecreasethelevelofVEGF.【Ke
7、ywords】Advancednon-smallcelllungcance;Erlotinib;Therapeuticevaluation;Gemcitabinehydrochloride;Cisplatin前言非小细胞肺癌在肺癌患者中所占的比例约为85%-90%,在患病过程中死亡率比较高,是导致肺癌患者死亡的主要因素[1-3]。在治疗过程中己经不在简单的手术和放疗化疗的模式,对非小细胞肺癌的治疗提出了靶向药物的治疗方法
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