浙江大学医学免疫学部分英文答案

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1、Questions:1.PleasedescribetheconceptsofTD-AgandTI-AgrespectivelyandcomparethedifferencesbetweenTD-AgandTI-Ag.Thymus-dependentantigensarethosethatdonotdirectlystimulatetheproductionofantibodywithoutthehelpofTcells.·Bcellepitope＋Tcellepitope·Humoralimmunityandcellularimmunity·Antibody:fivetypes·Immune

2、memoryProteinsarethymus-dependentantigens.Thymus-independentantigensareantigenswhichcandirectlystimulatetheBcellstoproduceantibodywithouttherequirementforTcellhelpIngeneral.·onlyBcellepitope·Humoralimmunity·Antibody:IgM·NoImmunememorypolysaccharidesareTI-antigens.2.Pleasedescribethegeneralproperties

3、ofcytokine.GeneralpropertiesofCKsnSmallproteins(MW:approx.15-30KD)nExtremelypotent,actingatpMorfMnTheproductionistransientandtightlyregulatednAutocrine,paracrineorendocrinenNon-specificandnon-MHCrestricted3.Whataretherulesofantibodyproductioninvivo?(Whatarethegeneralfeaturesofantibodyresponsesinvivo

4、?)BcellandHMIpptP65.表格作参考，表格下的文字为主。PrimaryresponseSecondaryresponseLagafterimmunizationUsually5-10daysUsually1-3daysPeakresponseSmallerLargerAntibodyisotypeUsuallyIgM>IgGRelativeincreaseinIgGand,undercertainsituations,inIgAorIgE(heavychainclassswitching)AntibodyaffinityLoweraverageaffinity,morevaria

5、bleHigheraverageaffinity(affinitymaturation)Primaryimmuneresponse-longerlatentphase;-smallerpeakresponse(lowerAbtiter);-remainingintheserumatdetectablelevelsformuchshorterperiods;-loweraverageaffinity;-usuallyIgM;Secondaryimmuneresponse(Theimmuneresponsefollowedbysecondaryantigenicchallenge)-shorter

6、latentphase;-biggerpeakresponse(higherAbtiter);-remainingintheserumatdetectablelevelsformuchlongerperiods;-higheraverageaffinity;-usuallyIgG.1.PleasedescribethegeneralprocessofCD4+Tcellmediatedimmuneresponse.2.PleasedescribethecomponentsandpathogenicmechanisminvolvedintypeⅠhypersensitivity.Component

7、sinvolvedintypeIhypersensitivity•AllergensareproteinsorchemicalsboundtoproteinsthatinduceIgEantibodyresponsesandelicitanimmediatehypersensitivity(allergic)reactioninatopicindividuals.•Allerginisaspeci