浙江大学医学免疫学部分英文答案

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1、Questions:1.PleasedescribetheconceptsofTD-AgandTI-AgrespectivelyandcomparethedifferencesbetweenTD-AgandTI-Ag.Thymus-dependentantigensarethosethatdonotdirectlystimulatetheproductionofantibodywithoutthehelpofTcells.·Bcellepitope＋Tcellepitope·Humoralimmunityandcellu

2、larimmunity·Antibody:fivetypes·ImmunememoryProteinsarethymus-dependentantigens.Thymus-independentantigensareantigenswhichcandirectlystimulatetheBcellstoproduceantibodywithouttherequirementforTcellhelpIngeneral.·onlyBcellepitope·Humoralimmunity·Antibody:IgM·NoImmu

3、nememorypolysaccharidesareTI-antigens.2.Pleasedescribethegeneralpropertiesofcytokine.GeneralpropertiesofCKsnSmallproteins(MW:approx.15-30KD)nExtremelypotent,actingatpMorfMnTheproductionistransientandtightlyregulatednAutocrine,paracrineorendocrinenNon-specificandn

4、on-MHCrestricted3.Whataretherulesofantibodyproductioninvivo?(Whatarethegeneralfeaturesofantibodyresponsesinvivo?)BcellandHMIpptP65.表格作参考，表格下的文字为主。PrimaryresponseSecondaryresponseLagafterimmunizationUsually5-10daysUsually1-3daysPeakresponseSmallerLargerAntibodyiso

5、typeUsuallyIgM>IgGRelativeincreaseinIgGand,undercertainsituations,inIgAorIgE(heavychainclassswitching)AntibodyaffinityLoweraverageaffinity,morevariableHigheraverageaffinity(affinitymaturation)Primaryimmuneresponse-longerlatentphase;-smallerpeakresponse(lowerAbtit

6、er);-remainingintheserumatdetectablelevelsformuchshorterperiods;-loweraverageaffinity;-usuallyIgM;Secondaryimmuneresponse(Theimmuneresponsefollowedbysecondaryantigenicchallenge)-shorterlatentphase;-biggerpeakresponse(higherAbtiter);-remainingintheserumatdetectabl

7、elevelsformuchlongerperiods;-higheraverageaffinity;-usuallyIgG.1.PleasedescribethegeneralprocessofCD4+Tcellmediatedimmuneresponse.2.PleasedescribethecomponentsandpathogenicmechanisminvolvedintypeⅠhypersensitivity.ComponentsinvolvedintypeIhypersensitivity•Allergen

8、sareproteinsorchemicalsboundtoproteinsthatinduceIgEantibodyresponsesandelicitanimmediatehypersensitivity(allergic)reactioninatopicindividuals.•Allerginisaspeci