浙江大学医学免疫学部分英文答案

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1、Questions:1.PleasedescribetheconceptsofTD-AgandTI-AgrespectivelyandcomparethedifferencesbetweenTD-AgandTI-Ag.Thymus-dependentantigensarethosethatdonotdirectlystimulatetheproductionofantibodywithoutthehelpofTcells.·Bcellepitope＋Tcellepitope·Humoralimmunityandcel

2、lularimmunity·Antibody:fivetypes·ImmunememoryProteinsarethymus-dependentantigens.Thymus-independentantigensareantigenswhichcandirectlystimulatetheBcellstoproduceantibodywithouttherequirementforTcellhelpIngeneral.·onlyBcellepitope·Humoralimmunity·Antibody:IgM·No

3、ImmunememorypolysaccharidesareTI-antigens.2.Pleasedescribethegeneralpropertiesofcytokine.GeneralpropertiesofCKsnSmallproteins(MW:approx.15-30KD)nExtremelypotent,actingatpMorfMnTheproductionistransientandtightlyregulatednAutocrine,paracrineorendocrinenNon-specif

4、icandnon-MHCrestricted3.Whataretherulesofantibodyproductioninvivo?(Whatarethegeneralfeaturesofantibodyresponsesinvivo?)BcellandHMIpptP65.表格作参考，表格下的文字为主。PrimaryresponseSecondaryresponseLagafterimmunizationUsually5-10daysUsually1-3daysPeakresponseSmallerLargerAnt

5、ibodyisotypeUsuallyIgM>IgGRelativeincreaseinIgGand,undercertainsituations,inIgAorIgE(heavychainclassswitching)AntibodyaffinityLoweraverageaffinity,morevariableHigheraverageaffinity(affinitymaturation)Primaryimmuneresponse-longerlatentphase;-smallerpeakresponse(

6、lowerAbtiter);-remainingintheserumatdetectablelevelsformuchshorterperiods;-loweraverageaffinity;-usuallyIgM;Secondaryimmuneresponse(Theimmuneresponsefollowedbysecondaryantigenicchallenge)-shorterlatentphase;-biggerpeakresponse(higherAbtiter);-remainingintheseru

7、matdetectablelevelsformuchlongerperiods;-higheraverageaffinity;-usuallyIgG.1.PleasedescribethegeneralprocessofCD4+Tcellmediatedimmuneresponse.2.PleasedescribethecomponentsandpathogenicmechanisminvolvedintypeⅠhypersensitivity.ComponentsinvolvedintypeIhypersensit

8、ivity•AllergensareproteinsorchemicalsboundtoproteinsthatinduceIgEantibodyresponsesandelicitanimmediatehypersensitivity(allergic)reactioninatopicindividuals.•Allerginisaspeci