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1、Student:ShamsiyaMentor:MaynurFromOncologydepartmentCervicalCancer宫颈癌Student:ShamsiyaMentor:MaynurFromOncologydepartmentCervixLowerpartoftheuterusConnectsthebodyoftheuterustothevagina(birthcanal)Source:AmericanCancerSocietyStatistics10,520newcasesintheU.S.thisyear3,900willdie5

2、0%arediagnosedbetweenages35and55.20%attheageof65orover.Rarelyoccursinwomenyoungerthan20Noninvasiveisfourtimesmorecommon74%decreaseindeathsbetween1955and1992intheU.S.Deathratecontinuoustodeclineby2%ayearSource:AmericanCancerSocietyThreeTypesSquamouscellCarcinomasCancerofflatep

3、ithelialcell80%to90%AdenocarcinomasCancerarisingfromglandularepithelium10%-20%MixedcarcinomaFeaturesbothtypesCervicalCancerBeginsintheliningofthecervixCellschangefromnormaltopre-cancer(dysplasia)andthentocancerRiskFactorsHumanpapillomavirusinfection(HPV)–PrimaryfactorHPV16,HP

4、V18,HPV31,HPV33,HPV4550%arecausedbyHPV16AND18SexualbehaviorSmokingHIVinfectionChlamydiainfectionDietOralcontraceptivesMultiplepregnanciesLowsocioeconomicstatusDiethylstilbestrol(DES)FamilyhistorySource:AmericanCancerSocietySignsandSymptomsVaginalbleedingMenstrualbleedingislon

5、gerandheavierthanusualBleedingaftermenopauseorincreasedvaginaldischargeBleedingfollowingintercourseorpelvicexamPainduringintercourseSource:AmericanCancerSocietyDiagnosisCervicalCytology(PapTest)Cellsareremovedfromthecervixandexaminedunderthemicroscope.Candetectepithelialcella

6、bnormalitiesAtypicalsquamouscellsSquamousintraepitheliallesionsSquamouscellcarcinoma(likelytobeinvasive)Source:AmericanCancerSocietyDiagnosisAdditionaltestingColposcopyCervixisviewedthroughacolposcopeandthesurfaceofthecervixcanbeseencloseandclear.CervicalBiopsiesColposcopicbi

7、opsy–removalofsmallsectionoftheabnormalareaofthesurface.Endocervicalcurettage–removingsometissueliningfromtheendocervicalcanal.Conebiopsy–cone-shapedpieceoftissueisremovedfromthecervixStagingFIGOSystem(InternationalFederationOfGynecologyandObstetrics)Hasfivestages–0to4Stage0C

8、arcinomainsituStage1Invadedcervix,buthasnotspread.Stage2Hasspreadton