宫颈癌讲课-PPT文档课件.ppt

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1、CervixLowerpartoftheuterusConnectsthebodyoftheuterustothevagina(birthcanal)Source:AmericanCancerSocietyStatistics10,520newcasesintheU.S.thisyear3,900willdie50%arediagnosedbetweenages35and55.20%attheageof65orover.Rarelyoccursinwomenyoungerthan20Noninvasiveisfourtimesmorecommon74%decreaseindea

2、thsbetween1955and1992intheU.S.Deathratecontinuoustodeclineby2%ayearSource:AmericanCancerSocietyThreeTypesSquamouscellCarcinomasCancerofflatepithelialcell80%to90%AdenocarcinomasCancerarisingfromglandularepithelium10%-20%MixedcarcinomaFeaturesbothtypesCervicalCancerBeginsintheliningofthecervix

3、Cellschangefromnormaltopre-cancer(dysplasia)andthentocancerRiskFactorsHumanpapillomavirusinfection(HPV)–PrimaryfactorHPV16,HPV18,HPV31,HPV33,HPV4550%arecausedbyHPV16AND18SexualbehaviorSmokingHIVinfectionChlamydiainfectionDietOralcontraceptivesMultiplepregnanciesLowsocioeconomicstatusDiethyls

4、tilbestrol(DES)FamilyhistorySource:AmericanCancerSocietySignsandSymptomsVaginalbleedingMenstrualbleedingislongerandheavierthanusualBleedingaftermenopauseorincreasedvaginaldischargeBleedingfollowingintercourseorpelvicexamPainduringintercourseSource:AmericanCancerSocietyDiagnosisCervicalCytolo

5、gy(PapTest)Cellsareremovedfromthecervixandexaminedunderthemicroscope.CandetectepithelialcellabnormalitiesAtypicalsquamouscellsSquamousintraepitheliallesionsSquamouscellcarcinoma(likelytobeinvasive)Source:AmericanCancerSocietyDiagnosisAdditionaltestingColposcopyCervixisviewedthroughacolposcop

6、eandthesurfaceofthecervixcanbeseencloseandclear.CervicalBiopsiesColposcopicbiopsy–removalofsmallsectionoftheabnormalareaofthesurface.Endocervicalcurettage–removingsometissueliningfromtheendocervicalcanal.Conebiopsy–cone-shapedpieceoftissueisremovedfromthecervixStagingFIGOSystem(International

7、FederationOfGynecologyandObstetrics)Hasfivestages–0to4Stage0CarcinomainsituStage1Invadedcervix,buthasnotspread.Stage2Hasspreadtonearbyareas,notleavingpelvicarea.Stage3Cancerhasspreadtothelowerpartofthevagina.Stage4Cancerhasspreadtonearbyorgans;meta