《宫颈癌讲课》ppt课件

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1、Student:ShamsiyaMentor:MaynurFromOncologydepartmentCervicalCancer宫颈癌Student:ShamsiyaMentor:MaynurFromOncologydepartmentCervixLowerpartoftheuterusConnectsthebodyoftheuterustothevagina(birthcanal)Source:AmericanCancerSocietyStatistics10,520newcasesintheU.S.thisyear3,900willdie50%arediagn

2、osedbetweenages35and55.20%attheageof65orover.Rarelyoccursinwomenyoungerthan20Noninvasiveisfourtimesmorecommon74%decreaseindeathsbetween1955and1992intheU.S.Deathratecontinuoustodeclineby2%ayearSource:AmericanCancerSocietyThreeTypesSquamouscellCarcinomasCancerofflatepithelialcell80%to90%

3、AdenocarcinomasCancerarisingfromglandularepithelium10%-20%MixedcarcinomaFeaturesbothtypesCervicalCancerBeginsintheliningofthecervixCellschangefromnormaltopre-cancer(dysplasia)andthentocancerRiskFactorsHumanpapillomavirusinfection(HPV)–PrimaryfactorHPV16,HPV18,HPV31,HPV33,HPV4550%arecau

4、sedbyHPV16AND18SexualbehaviorSmokingHIVinfectionChlamydiainfectionDietOralcontraceptivesMultiplepregnanciesLowsocioeconomicstatusDiethylstilbestrol(DES)FamilyhistorySource:AmericanCancerSocietySignsandSymptomsVaginalbleedingMenstrualbleedingislongerandheavierthanusualBleedingaftermenop

5、auseorincreasedvaginaldischargeBleedingfollowingintercourseorpelvicexamPainduringintercourseSource:AmericanCancerSocietyDiagnosisCervicalCytology(PapTest)Cellsareremovedfromthecervixandexaminedunderthemicroscope.CandetectepithelialcellabnormalitiesAtypicalsquamouscellsSquamousintraepit

6、heliallesionsSquamouscellcarcinoma(likelytobeinvasive)Source:AmericanCancerSocietyDiagnosisAdditionaltestingColposcopyCervixisviewedthroughacolposcopeandthesurfaceofthecervixcanbeseencloseandclear.CervicalBiopsiesColposcopicbiopsy–removalofsmallsectionoftheabnormalareaofthesurface.Endo

7、cervicalcurettage–removingsometissueliningfromtheendocervicalcanal.Conebiopsy–cone-shapedpieceoftissueisremovedfromthecervixStagingFIGOSystem(InternationalFederationOfGynecologyandObstetrics)Hasfivestages–0to4Stage0CarcinomainsituStage1Invadedcervix,buthasnotspread.Stage2Hasspreadton