《宫颈癌讲课》课件.pptx

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1、Student:ShamsiyaMentor:MaynurFromOncologydepartmentCervicalCancer宫颈癌Student:ShamsiyaMentor:MaynurFromOncologydepartmentCervixLowerpartoftheuterusConnectsthebodyoftheuterustothevagina(birthcanal)Source:AmericanCancerSocietyStatistics10,520newcasesintheU.S.thisye

2、ar3,900willdie50%arediagnosedbetweenages35and55.20%attheageof65orover.Rarelyoccursinwomenyoungerthan20Noninvasiveisfourtimesmorecommon74%decreaseindeathsbetween1955and1992intheU.S.Deathratecontinuoustodeclineby2%ayearSource:AmericanCancerSocietyThreeTypesSquamo

3、uscellCarcinomasCancerofflatepithelialcell80%to90%AdenocarcinomasCancerarisingfromglandularepithelium10%-20%MixedcarcinomaFeaturesbothtypesCervicalCancerBeginsintheliningofthecervixCellschangefromnormaltopre-cancer(dysplasia)andthentocancerRiskFactorsHumanpapil

4、lomavirusinfection(HPV)–PrimaryfactorHPV16,HPV18,HPV31,HPV33,HPV4550%arecausedbyHPV16AND18SexualbehaviorSmokingHIVinfectionChlamydiainfectionDietOralcontraceptivesMultiplepregnanciesLowsocioeconomicstatusDiethylstilbestrol(DES)FamilyhistorySource:AmericanCancer

5、SocietySignsandSymptomsVaginalbleedingMenstrualbleedingislongerandheavierthanusualBleedingaftermenopauseorincreasedvaginaldischargeBleedingfollowingintercourseorpelvicexamPainduringintercourseSource:AmericanCancerSocietyDiagnosisCervicalCytology(PapTest)Cellsar

6、eremovedfromthecervixandexaminedunderthemicroscope.CandetectepithelialcellabnormalitiesAtypicalsquamouscellsSquamousintraepitheliallesionsSquamouscellcarcinoma(likelytobeinvasive)Source:AmericanCancerSocietyDiagnosisAdditionaltestingColposcopyCervixisviewedthro

7、ughacolposcopeandthesurfaceofthecervixcanbeseencloseandclear.CervicalBiopsiesColposcopicbiopsy–removalofsmallsectionoftheabnormalareaofthesurface.Endocervicalcurettage–removingsometissueliningfromtheendocervicalcanal.Conebiopsy–cone-shapedpieceoftissueisremoved

8、fromthecervixStagingFIGOSystem(InternationalFederationOfGynecologyandObstetrics)Hasfivestages–0to4Stage0CarcinomainsituStage1Invadedcervix,buthasnotspread.Stage2Hasspreadton