Lp-PLA2：心血管事件新的独立预测因子PPT课件.ppt

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1、InflammatoryEnzymesinCardiovascularDisease:AFocusonLp-PLA2ProgramIntroductiontoCardiovascularDiseaseAtherosclerosis–AnInflammatoryDisorderMarkersofInflammationEpidemiologicalStudieslinkingLp-PLA2withCHDTheRoleofLp-PLA2inScreeningandManagingPatientswithCHDCardiovascularDiseasesManyadvances,but

2、farfromconqueredCardiovasculardiseasesaretheprimecauseofmortalityintheUnitedStatesandaroundtheworldMortalityfromCVdiseaseisgreaterthanthatofthenext7causesofdeathcombinedCosttosociety:over$130billiondollarsin2003Willcontinuetobeanevengreaterconcernduetoan:Explosiveincreaseinobesity,diabetes,hy

3、pertensionandatheroscleroticvasculardiseaseAgingpopulation-40millionAmericanswillbeover65in2010-withassociateddiseaseconsequencesHeartDisease&StrokeStatistics–2004Update,AHA;NHANESIII(1988-1994);ARIC,NHLBI(1987-1994)TheImportanceofCoronaryHeartDiseaseCoronaryHeartDisease(CHD)istheleadingcaus

4、eofdeathinmenandwomenintheUnitedStatesandmuchofthewesternworldOver500,000deaths,ormorethan1ofevery5deaths,intheUnitedStatesin2000Incidence:Over1millionMIcaseseachyear,upto44%resultindeathPrevalence:Over12millioncasesofanginaBroadrangeofagesMenandwomenAllsocioeconomicsectorsMajorsocialandecono

5、micconsequencesHeartDiseaseandStrokeStatistics–2004UpdateUnmetNeedInspiteofmajoradvancesmadeinthescreening,detection,andmanagementofheartdisease,amajorneedexistsformorewaystopredictCVriskApproximately50%ofindividualsdiagnosedwithcoronaryarterydiseasedonothavehighbloodcholesterollevelsTherefor

6、e,otherfactorsmustbeinvolved50%ofCHDOccursinPeopleWithBelowAverageTCAdaptedfromCastelliW.Atherosclerosis1996;124(suppl):S1-S9.FraminghamHeartStudy—26-YearFollow-up150200NoCHDTotalCholesterol(mg/dL)250300CHDAtheroscleroticPlaqueDevelopmentLibbyP.AtlasofHeartDiseases:Atherosclerosis:RiskFacto

7、rsandTreatment.EditedbyPeterW.F.Wilson.2003.(withpermission)RoleofInflammatoryCellsinAtherosclerosisandPlaqueVulnerabilityAdaptedfrom:LibbyP.SciAmer2001;May:47-55.AtherosclerosisisaprogressiveinflammatorydiseasethatdevelopsovermanyyearsInflam