t淋巴细胞亚群及血小板相关参数在儿童免疫性血小板减少症发病中的研究分析

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1、T淋巴细胞亚群及血小板相关参数在儿童免疫性血小板减少症发病中的研宄分析高长俊张晴韩洁韪莆唐山市妇幼保健院小儿血液科摘要：目的:探讨T淋巴细胞亚群及血小板相关参数在儿童免疫性血小板减少症(ITP)发病中的表达及意义。方法:选取2013年6月2015年6月唐山市妇幼保健院血液科病房收治的241例初诊TTP儿童作为观察组研究对象，另选取冋期健康儿童252例作为对照组，分别检测并比较两组T淋巴细胞亚群及血小板相关参数水平，并对两组中大于4岁的儿童进行生活质量问卷调斉，评估ITP患儿的生活质量。结果:观察组患儿CD3+、CD4+T淋巴细胞、CD4+/CD8+比值及PLT计数均

2、明显低于对照组水平，而CD8+T淋巴细胞、MPV及PDW明显高于对照组水平;与治疗前水平比较，治疗5日后TTP患儿T淋巴细胞亚群及血小板相关参数水平均有明显改善;方差分析结果显示，ITP患儿血小板计数、CD4+/CD8+与骨髓巨核细胞数间差异无统计学意义;KIT生活质量问卷调斉结果显示，ITP患儿治疗干预方而得分最高，为(1.89±1.06)分。结论：ITP患儿CD3+、CD4+T淋巴细胞、CD4+/CD8+比值及PLT计数均明显降低，CD8+T淋巴细胞、MPV及PDW明显升高，ITP患儿生活质量明显降低，T淋巴细胞亚群及血小板相关参数对TTP诊断具奋一定的临床价值

3、。关键词：T淋巴细胞亚群;血小板;免疫性血小板减少症;作者简介：高长俊，E-mail:287687659@qq.com收稿日期：2017-09-21AnalysisofTlymphocytesubsetsandplateletparametersinchildrenwithimmunethrombocytopeniaGaoChang-junZhangQingHanJieHanJinTheChildren'sBloodDepartmentofTangshanMaternalandChildCareHospital;Abstract：ObjectiveInvestiga

4、tetotheexpressionandsignificanceofTlymphocytesubsetsandplateletparametersinchi1drenwithimmunethrombocytopenia.MethodsFromJune2013toJune2015，241casesofnewlydiagnosedITPchildrenintheDepartmentofhematologywardofTangshanCitymaternalandchildhealthhospitalwereselectedastheobservationgroup.An

5、other252healthychildrenwereselectedascontrolgroup,andtheTlymphocytesubsetsandplateletrelatedparametersweredetectedandcomparedbetweenthetwogroups.ThequalityoflifeoftwogroupsofchildrenovertheageoffouryearswereinvestigatedtoevaluatethequalityoflifeofchildrenwithITP.ResultsTheTlymphocyteof

6、CD3+、CD4+,CD4+/CD8+ratioandPLTcountintheobservationgroupweresignificantlylowerthanthoseinthecontrolgroup,TheTlymphocytesofCD8+，MPVandPDWweresignificantlyhigherthanthoseinthecontrolgroup;Withthelevelbeforetreatment,fivedaysaftertreatmentwithITPTlymphocytesubsetsandplateletparameterlevel

7、sweresignificantlyimproved;Theresultsofvarianceanalysisshowedthattherewasnosignificantdifferenceinplateletcount,CD4+/CD8+andthenumberofbonemarrowmegakaryocyteinchildrenwithITP;TheresultsofKITqualityoflifequestionnaireshowedthatITPchildrenhadthehighestscoreoftreatmentintervention,thes