医学ppt药物化学英文版抗肿瘤药

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1、MedicinalChemistryAntineoplasticAgents班级：制药一班学生：张航AntineoplasticAgentsTumorformation1introduction2BasictheoryAntineoplasticAgents1AgentsDirectlyActingonDNA2AgentsInterferingwithDNASynthesis3AntimitoticAgents4AgentsonSignalTransductionPathwayMechanismofTunor(Erlotin

2、ib)Tumorprevention1Primarypreventionoftumor2Secondarypreventionoftumor3TertiarypreventionoftumorAntineoplasticAgentsTumorformation1、IntroductionAntineoplasticAgents1)BasiccharacteristicsofTumorcells——cellularatypia2)Biologicalbehavioroftumors——heterogeneityAntineop

3、lasticAgentsNormalcellCarcinogen-inducedchangeTumorcellvariantAntineoplasticAgentsTumorformation2Basictheory1)Cancerisageneticdisease2)MonoclonalexpansionofTumorcells3)Oncogeneactivationortumorsuppressorgeneinactivation4)Long-term,phased,multiplemutationsaccumulate

4、dintheprocess5)TheresultoflossoffunctionofimmunesurveillanceAntineoplasticAgentsAntineoplasticAgents1)AgentsDirectlyActingonDNAAlkylatingAgentsPlatinumComplexesTopoisomeraseInhibitors2)AgentsInterferingwithDNASynthesisAntifolatesPyrimidineAntimetabolitesPurineAntim

5、etabolitesAntineoplasticAgents3)AntimitoticAgentsAntitumorAgentsHavingOneBinding-PointonTubulinAntitumorAgentsHavingTwoBinding-PointonTubulinAntitumorAgentsActingonthePolymerizationStateofMicrotube4)AgentsonSignalTransductionPathwayMechanismofTunorProteinKinaseInhi

6、bitorsProteasomeInhibitorsAntineoplasticAgentsErlotinibandGefitinibAntineoplasticAgentsAntineoplasticAgentsErlotinibTarceva®(erlotinib),aonce-a-daypill,wasoneofthefirsttargetedtreatmentsapprovedbytheU.S.FoodandDrugAdministration(FDA)specificallydesignedtotargetthee

7、pidermalgrowthfactorreceptor(EGFR)pathway.TarcevahasbeenshowntohelpsomepeoplewithadvancedNSCLCandadvancedpancreaticcancerlivelonger.NSCLC(Non-small-cellcarcinoma)AntineoplasticAgentsErlotinibChemicalcompositionC22H23N3O4氮一(3一乙炔苯)一6，7一二(甲氧己氧)一4一喹唑啉胺AntineoplasticAge

8、ntsErlotinibMechanismofActionTarcevaisdesignedtoinhibitsignalingoftheepidermalgrowthfactorreceptor(EGFR)pathway.Tarcevaworksinsidethetumorcellbyi