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1、Therapeuticvaccinesforhypertension治疗性降压疫苗研究进展LiaoYu-Hua,MD.InstituteofCardiology,UnionhospitalHuazhongUniversityofScience&TechnologyWuhan,ChinaFoshan,2008WorldCongressofVaccineRenin-AngiotensinSysteminvolvedinpathogenesisofhypertensionAngiotensinogenAngiotensinIAngiotensinIIATR1VasoconstructionVo
2、lumeretensionACEReninChemicalDrugsRenininhibitorACEIangiotensin-convertingenzymeinhibitorARBAngiotensinreceptorblockerHypertensionFoshan,2008WorldCongressofVaccineUICUnionInstituteofCardiologyAstory：fromautoantibodiesofhypertensiontovaccinesofhypertension(HT)AutoantibodiesinHT?Autoimmunedamage?Da
3、ngerouswarningPathogenesisofHTpreventionandtreatmentofHTSafetysignalFoshan,2008WorldCongressofVaccineUICUnionInstituteofCardiologyEvidencesofautoantibodiesagainstG-proteincoupledreceptorinpatientswithhypertensionPrevalenceofAntiAT1receptorAbPrevalenceofAntiα1-adrenoceptorAbPrimaryHypertensiontota
4、l26.8%(Liao，2002)25.3%(Liao，2002)44%(Luther，1997)refractory42.9%(Liao，2002)36.7%(Liao，2002)78%(Homuth，2003)non-refractory10.4%(Liao，2002)13.5%(Liao，2002)MalignantHypertension14-33%(Fu，2000)20%(Fu，1994)SecondaryHypertension14%(Fu，2000)64%(Fu，2000)FuML,etal.Lancet.1994;344:1660-1663LutherHP,etal.Hy
5、pertension.1997;29:678-682FuML,etal.JHypertens.2000;18:945-953LiaoYH,etal.HypertensRes.2002;25:641–646.HomuthV,etal.Hypertonie2003(onlinearticle)Foshan,2008WorldCongressofVaccineUICUnionInstituteofCardiologyArterialremodelingwasgeneratedafter1yearimmunizedbyEC2peptideofAT1-receptorinWistarratsBin
6、Wang,Yu-HuaLiao,etal.HeartandVessel,2005;20(4):153-8.BeforeimmuneAyearafterimmune**p<0.01EC2ofratAT1-receptorwithtetanus-toxoidandCFAAntibodyagainstAT1receptorUICUnionInstituteofCardiologyWhyresearchvaccineforhypertension?Primaryhypertensionisn’trecognizedanautoimmunedesease,becauseofwithoutautoi
7、mmunedamageintargetorgansButthereisautoimmuneresponseinhypertension,becausewefoundtheautoantibodiesagainstAT1receptorinpatientswithhypertensionFoshan,2008WorldCongressofVaccineUICUnionInstituteofCardiologyAstory：fromau
