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1、RESEARCHEffectsofglucosamine,chondroitin,orplaceboinpatientswithosteoarthritisofhiporknee:networkmeta-analysisSimonWandel,researchfellow,1,2PeterJu¨ni,professorandheadofdivision,1,2BrittaTendal,researchfellow,3EvelineNu¨esch,researchfellow,1,2PeterMVilliger,director,4NickyJWelton,seniorre
2、searchfellow,5StephanReichenbach,seniorresearchfellow,1,4SvenTrelle,seniorresearchfellow1,21InstituteofSocialandPreventiveABSTRACTinflammatorydrugs,butthesedrugscancauseseriousMedicine,UniversityofBern,ObjectiveTodeterminetheeffectofglucosamine,gastrointestinalandcardiovascularadverseeven
3、ts,Switzerlandchondroitin,orthetwoincombinationonjointpainand122especiallywithlongtermuse.DiseasemodifyingCTUBern,BernUniversityHospital,Switzerlandonradiologicalprogressionofdiseaseinosteoarthritisofagentsthatnotonlyreducejointpainbutalsoslow3NordicCochraneCentre,thehiporknee.theprogress
4、ionoftheconditionwouldbedesirable.Righospitalet,Copenhagen,DesignNetworkmeta-analysis.DirectcomparisonswithinThroughouttheworldforthepast10years,thecarti-Denmarktrialswerecombinedwithindirectevidencefromotherlageconstituentschondroitinandglucosaminehave4DepartmentofRheumatology,trialsbyus
5、ingaBayesianmodelthatallowedthebeenincreasinglyrecommendedinguidelines,pre-ClinicalImmunology,andAllergology,BernUniversitysynthesisofmultipletimepoints.scribedbygeneralpractitionersandrheumatologists,Hospital,SwitzerlandMainoutcomemeasurePainintensity.Secondaryandusedbypatientsasoverthec
6、ountermedicationsto5AcademicUnitofPrimaryHealthoutcomewaschangeinminimalwidthofjointspace.ThemodifytheclinicalandradiologicalcourseoftheCare,DepartmentofCommunity3minimalclinicallyimportantdifferencebetweencondition.GlobalsalesofglucosaminesupplementsBasedMedicine,UniversityofBristol,Bris
7、tol,UnitedKingdompreparationsandplacebowasprespecifiedat−0.9cmonreachedalmost$2bn(£1.3bn,€0.8bn)in2008,whichCorrespondenceto:PJüni,Institutea10cmvisualanaloguescale.representsanincreaseofabout60%comparedwithofSocialandPreventiveMedicine,DatasourcesElectronicdatabase
