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1、Downloadedfromard.bmj.comonOctober19,2011-Publishedbygroup.bmj.comExtendedreportChondroitinsulphatereducesbothcartilagevolumelossandbonemarrowlesionsinkneeosteoarthritispatientsstartingasearlyas6monthsafterinitiationoftherapy:arandomised,double-blind,placebo-controlledpilotstu
2、dyusingMRILukasMartinWildi,1Jean-PierreRaynauld,1JohanneMartel-Pelletier,1AndréBeaulieu,2LouisBessette,3FrédéricMorin,4FrançoisAbram,5MarcDorais,6Jean-PierrePelletier1▶AdditionaldataABSTRACTalthoughrecognisedbytheauthorities,mightnot(supplementarytext)areObjectiveTodetermineth
3、eeffectofchondroitinsulphatehavefullyexploredthedrugs’protectiveeffectaspublishedonlineonly.Toview(CS)treatmentoncartilagevolumeloss,subchondralbonethistechniqueallowsforonlyanindirectassess-thesearticlespleasevisitthejournalonline(http://ard.bmj.marrowlesions(BML),synovitisan
4、ddiseasesymptomsinmentofthecartilage.RecentadvancesinMRIhavecom).patientswithkneeosteoarthritis(OA).enabledinvestigatorstoquantitativelyandreliably¹OsteoarthritisResearchUnit,MethodsInthispilotmulticentre,randomised,double-assesscartilagethicknessandvolume,aswellasUniversityof
5、MontrealHospitalblind,controlledtrialinprimarykneeOA,69patientswiththeotherjointstructuralchangesoccurringintheResearchCentre(CRCHUM),clinicalsignsofsynovitiswererandomisedtoreceiveCSsubchondralbone,menisciandsynovium.15–22TheNotre-DameHospital,Montreal,800mgorplacebooncedaily
6、for6monthsfollowedbyusefulnessofMRItechnologyinthecontextofclin-Canada2anopen-labelphaseof6monthsinwhichpatientsinbothicaltrialsexploringDMOADeffectshasrecentlyFacultyofMedicine,UniversityofLaval,Québec,CanadagroupsreceivedCS800mgoncedaily.Cartilagevolumebeendemonstrated.14233
7、GroupedeRechercheenandBMLwereassessedbyMRIatbaselineandat6andCSbelongstotheglycosaminoglycansandisaRhumatologieetMaladies12months;synovialmembranethicknesswasassessedmajorcomponentofarticularcartilage.OnOAjointOsseuses(GRMO),Sainte-Foy,atbaselineandat6months.tissues,CShasbeens
8、howntomodifythechondro-Canada4CentredeRechercheMusculo-Result
