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1、Thenewenglandjournalofmedicineestablishedin1812february23,2006vol.354no.8Glucosamine,ChondroitinSulfate,andtheTwoinCombinationforPainfulKneeOsteoarthritisDanielO.Clegg,M.D.,DomenicJ.Reda,Ph.D.,CrystalL.Harris,Pharm.D.,MargueriteA.Klein,M.S.,JamesR.O’Dell,M.D.,MicheleM.Hooper,M.D.,JohnD.Bradley
2、,M.D.,CliftonO.BinghamIII,M.D.,MichaelH.Weisman,M.D.,ChristopherG.Jackson,M.D.,NancyE.Lane,M.D.,JohnJ.Cush,M.D.,LarryW.Moreland,M.D.,H.RalphSchumacher,Jr.,M.D.,ChesterV.Oddis,M.D.,FrederickWolfe,M.D.,JerryA.Molitor,M.D.,DavidE.Yocum,M.D.,ThomasJ.Schnitzer,M.D.,DanielE.Furst,M.D.,AllenD.Sawitzk
3、e,M.D.,HelenShi,M.S.,KennethD.Brandt,M.D.,RolandW.Moskowitz,M.D.,andH.JamesWilliams,M.D.abstractBackgroundGlucosamineandchondroitinsulfateareusedtotreatosteoarthritis.Themulti-FromtheUniversityofUtahSchoolofcenter,double-blind,placebo-andcelecoxib-controlledGlucosamine/chondroitinMedicine,Salt
4、LakeCity(D.O.C.,C.G.J.,A.D.S.,H.J.W.);theHinesVeteransArthritisInterventionTrial(GAIT)evaluatedtheirefficacyandsafetyasatreatmentAffairsCooperativeStudiesProgramforkneepainfromosteoarthritis.CoordinatingCenter,Hines,Ill.(D.J.R.,H.S.);theClinicalResearchPharmacyMethodsCoordinatingCenter,Albuque
5、rque,N.M.Werandomlyassigned1583patientswithsymptomatickneeosteoarthritistore-(C.L.H.);theNationalCenterforCom-plementaryandAlternativeMedicine,ceive1500mgofglucosaminedaily,1200mgofchondroitinsulfatedaily,bothNationalInstitutesofHealth,Bethesda,glucosamineandchondroitinsulfate,200mgofcelecoxib
6、daily,orplacebofor24Md.(M.A.K.);theUniversityofNebraskaweeks.Upto4000mgofacetaminophendailywasallowedasrescueanalgesia.MedicalCenter,Omaha(J.R.O.);CaseWesternReserveUniversity,ClevelandAssignmentwasstratifiedaccordingtotheseverityofkneepain(mild[N=1229](M.M.H.,R.W.M.);theIndianaUniversityvs.mo
7、deratetosevere[N=354]).Theprimaryoutcomemeasurewasa20percentSchoolofMedicine,Indianapolis(J.D.B.,decreaseinkneepainfrombaselinetoweek24.K.D.B.);theHospitalforJointDiseases,RheumatologyandMedicine,NewYorkResults(C.O.B.);Cedars-SinaiMedic
