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1、ORIGINALINVESTIGATIONStructuralandSymptomaticEfficacyofGlucosamineandChondroitininKneeOsteoarthritisAComprehensiveMeta-analysisFlorentRichy,MSc;OlivierBruyere,MSc;OlivierEthgen,MSc;MichelCucherat,MSc,PhD;YvesHenrotin,MSc,PhD;Jean-YvesReginster,MD,PhDObjective:Toassessthestructuralandsymptomaticef
2、-proacheswereusedforclearassessmentofpotentialef-ficacyoforalglucosaminesulfateandchondroitinsul-ficacy.fateinkneeosteoarthritisthroughindependentmeta-analysesoftheireffectsonjointspacenarrowing,LequesneResults:OurresultsdemonstratedahighlysignificantIndex,WesternOntarioMacMasterUniversityOsteoar
3、-efficacyofglucosamineonalloutcomes,includingjointthritisIndex(WOMAC),visualanalogscaleforpain,mo-spacenarrowingandWOMAC.Chondroitinwasfoundbility,safety,andresponsetotreatment.tobeeffectiveonLequesneIndex,visualanalogscalepain,mobility,andrespondingstatus.SafetywasexcellentforMethods:Anexhaustiv
4、esystematicresearchofran-bothcompounds.domized,placebo-controlledclinicaltrialspublishedorperformedbetweenJanuary1980andMarch2002thatConclusions:Ourstudydemonstratesthestructuralef-assessedtheefficacyoforalglucosamineorchondroitinficacyofglucosamineandindistinguishablesymptom-ongonarthrosiswasper
5、formedusingMEDLINE,aticefficaciesforbothcompounds.Regardingtherela-PREMEDLINE,EMBASE,CochraneDatabaseofSystem-tivelysparsedataonglucosamineandjointspaceaticReviews,CurrentContents,BIOSISPreviews,Health-narrowingandtheabsenceofdataonstructuraleffectsSTAR,EBMReviews,manualreviewoftheliteratureandof
6、chondroitin,furtherstudiesareneededtoinvestigatecongressionalabstracts,anddirectcontactwiththeau-therelationshipamongtime,dose,patientbaselinechar-thorsandmanufacturersofglucosamineandchondroi-acteristics,andstructuralefficacyforanaccurate,disease-tin.Inclusion,qualityscoring,anddataabstractionwe
7、remodifyingcharacterizationofthese2compounds.performedsystematicallyby2independentreviewerswhowereblindedtosourcesandauthors.Conservativeap-ArchInternMed.2003;163:1514-1522USCULOSKELETALdis-directlywiththediseaseprogre
