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1、ORIGINALCONTRIBUTIONEffectofGlucosamineonPain-RelatedDisabilityinPatientsWithChronicLowBackPainandDegenerativeLumbarOsteoarthritisARandomizedControlledTrialPhilipWilkens,MChiroContextChroniclowbackpain(LBP)withdegenerativelumbarosteoarthritis(OA)IngerB.Scheel,PhDiswidespreadintheadultpo
2、pulation.AlthoughglucosamineisincreasinglyusedbyOliverGrundnes,PhDpatientswithchronicLBP,littleisknownaboutitseffectinthissetting.ObjectiveToinvestigatetheeffectofglucosamineinpatientswithchronicLBPandChristianHellum,MDdegenerativelumbarOA.KjerstiStorheim,PhDDesign,Setting,andParticipan
3、tsAdouble-blind,randomized,placebo-STEOARTHRITIS(OA)ISAcontrolledtrialconductedatOsloUniversityHospitalOutpatientClinic,Oslo,Nor-commonconditionthatway,with250patientsolderthan25yearsofagewithchronicLBP(6months)andOcurrentlyaffectsmorethandegenerativelumbarOA.20millionindividualsinInte
4、rventionsDailyintakeof1500mgoforalglucosamine(n=125)orplacebotheUnitedStates,andthisnumberis(n=125)for6months,withassessmentofeffectafterthe6-monthinterventionpe-expectedtoincrease.1Liketheperiph-riodandat1year(6monthspostintervention).eraljoints,thespinedemonstratesMainOutcomeMeasuresT
5、heprimaryoutcomewaspain-relateddisabilitymea-osteoarthritic(facetjointchanges)andsuredwiththeRolandMorrisDisabilityQuestionnaire(RMDQ).Secondaryoutcomesdegenerativealterations(diskareawerenumericalscoresfrompain-ratingscalesofpatientsatrestandduringactivity,changes).2Thesefindingsareoft
6、enpres-andthequality-of-lifeEuroQol-5Dimensions(EQ-5D)instrument.Datacollectionoc-curredduringtheinterventionperiodatbaseline,6weeks,3and6months,andagainentindependentlyoflowbackpain36monthsfollowingtheinterventionat1year.Groupdifferenceswereanalyzedusing(LBP).Nevertheless,studiesindica
7、telinearmixedmodelsanalysis.thatsuchfindingsmaycauseLBP.2LowbackpainiswidespreadandistheResultsAtbaseline,meanRMDQscoreswere9.2(95%confidenceinterval[CI],8.4-10.0)forglucosamineand9.7(95%CI,8.9-10.5)fortheplacebogroup(P=.37).secondmostcommonconcernex-At6months,themeanRMDQscorew
