！effects of chondroitin and glucosamine sulfate

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1、EBMExperimentalBiologyandMedicineEffectsofChondroitinandGlucosamineSulfateinaDietaryBarFormulationonInflammation,Interleukin-1b,MatrixMetalloprotease-9,andCartilageDamageinArthritisMayM.Chou,NathalieVergnolle,JasonJ.McDougall,JohnL.Wallace,StephanieMarty,ValTeskeyandAndreG.BuretExperimentalBi

2、ologyandMedicine2005,230:255-262.Updatedinformationandservicescanbefoundat:http://ebm.rsmjournals.com/content/230/4/255©2008SocietyforExperimentalBiologyandMedicineDownloadedfromhttp://ebm.rsmjournals.com/byguestonOctober29,2011EffectsofChondroitinandGlucosamineSulfateinaDietaryBarFormulation

3、onInflammation,Interleukin-1b,MatrixMetalloprotease-9,andCartilageDamageinArthritisMAYM.CHOU,*NATHALIEVERGNOLLE,JASONJ.MCDOUGALL,àJOHNL.WALLACE,,1STEPHANIEMARTY,VALTESKEY,§ANDANDREG.BURET**DepartmentofBiologicalSciences,FacultyofScience,MucosalInflammationResearchGroup,DepartmentofPharmaco

4、logyandTherapeutics,FacultyofMedicine,MucosalInflammationResearchGroup,àDepartmentofPhysiologyandBiophysics,FacultyofMedicine,McCaigCentreforJointInjuryandArthritisResearch,UniversityofCalgary,Calgary,Alberta,Canada,T2N1N4;and§NewEraNutritionInc.,10250-176Street,Edmonton,Alberta,Canada,T5S1L2T

5、hisstudyexaminedtheeffectsofchondroitinsulfate(CS)inflammatory,andhistologicparametersofadjuvant-inducedaloneandCSplusglucosaminesulfate(GS)inadietarybararthritis.ThebenefitsofCSandGSincombinationaremoreformulationoninflammatoryparametersofadjuvant-inducedpronouncedthanthoseofCSalone.Thereduc

6、tionofarthriticarthritisandonthesynthesisofinterleukin-1b(IL-1b)andmatrixdiseasebyCSplusGSisassociatedwithareductionofIL-1bmetalloprotease-9(MMP-9).Following25dayspretreatmentwithandMMP-9synthesis.ExpBiolMed230:255–262,2005dietarybarscontainingeitherCSalone,CSplusGS,orneitherKeywords:chondroi

7、tin;glucosamine;MMP-9;IL-1b;cartilageCSnorGS,ratswereeithershaminjectedorinjectedwithFreund’scompleteadjuvantintothetailvein.Ratswerefedtheirrespectivebarsforanother17daysafterinoculation.Parame-tersofdiseaseexaminedincludedclinicalscore(comb