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1、EBMExperimentalBiologyandMedicineEffectofPre-LoadingOralGlucosamineHCl/ChondroitinSulfate/ManganeseAscorbateCombinationonExperimentalArthritisinRatsJoelBeren,SusanL.Hill,MarieDiener-WestandNoelR.RoseExperimentalBiologyandMedicine2001,226:144-151.Updatedinformationandservicescanbefoundat:http:/
2、/ebm.rsmjournals.com/content/226/2/144©2008SocietyforExperimentalBiologyandMedicineDownloadedfromhttp://ebm.rsmjournals.com/byguestonOctober12,2011EffectofPre-LoadingOralGlucosamineHCl/ChondroitinSulfate/ManganeseAscorbateCombinationonExperimentalArthritisinRats,1,1,,2JOELBEREN,*SUSANL.HILL,†M
3、ARIEDIENER-WEST,†ANDNOELR.ROSE*†*DepartmentofPathology,†TheW.HarryFeinstoneDepartmentofMolecularMicrobiologyandImmunology,and†DepartmentofBiostatistics,TheJohnsHopkinsMedicalInstitutions,Baltimore,Maryland21205Thetherapeuticeffectofanutritionalsupplementconsistingofheumatoidarthritis(RA)isasig
4、nificanthealthprob-acombinationofglucosaminehydrochloride(FCHG49),puri-lemintermsofnumbersofsufferers(U.S.incidencefiedsodiumchondroitinsulfate(TRH122),andmanganeseR323.7/100,000)andindegreeofassociateddisabilityascorbate(GCM)wasinvestigatedintheratmodelofcollagen-inducedautoimmunearthritis(CI
5、A).TheGCMcompoundwasaswell(1).Thediseaseischaracterizedbyachronicandmixedwithapalatablenutritionalpaste(Nutri-cal[NC]).Oraldestructiveinflammatoryreaction,possiblyautoimmuneinadministrationoftheNC/GCMcompoundwasinitiatedin26etiology,attackingthesynovialmembranesofjointsandrats10daysbeforeimmu
6、nizationandcontinueduntilthedayofmanyothertissuesofthebody.Muchhasbeenlearnedinsacrifice.Onegroupof12controlratswasgivennooralagents;asecondgroupof12controlratsreceivedNConly.EvaluationsrecentyearsaboutthepathogenesisofRA.Geneticpredis-includedarthritisindex(AI)scoringbythreeindependentevalu-p
7、ositionandexogenousarthritogensarebelievedtocontrib-ators,histologicindex(HI)scoringoflesions,T-cellprolifera-utetoaT-cell-mediatedautoimmunereactiontooneortion,andserologicalstudiesforantibodyclassesandsub-moreconstituentsofthejoint.So
