无糖尿病的中老年脑梗死患者胰岛素抵抗研究

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1、上海交通大学硕士学位论文无糖尿病的中老年脑梗死患者胰岛素抵抗研究姓名：喻曦霞申请学位级别：硕士专业：神经病学指导教师：苗玲20090422上海交通大学医学院硕士学位论文VI能是脑梗死的一个重要的危险因素，且它可能通过复杂的机制参与脑梗死的发生。关键词：胰岛素抵抗，脑梗死上海交通大学医学院硕士学位论文VIIANALYSISOFINSULINRESISTANCEINNON-DIABETICMIDDLE-AGEDANDOLDERPATIENTSWITHBRAININFARCTIONABSTRACTObjective:Toexploretherelationshipbetweeninsulin

2、resistanceandbraininfarctioninnon-diabeticmiddle-agedandolderpatients.Methods:Fastingbloodglucose,insulin,cortisol,growthhormone,C-peptideandbloodlipidsweremeasuredin30patientswithbraininfarctionand12patientswithoutbraininfarctionascontrolsubjectsallofwhomwereolderthan45yearsandnon-diabetic.Asam

3、easureofinsulinresistance,wecalculatedtheHomeostasisModelAssessmentofInsulinResistance;asameasureofβ-cellfunction,wecalculatedtheHomeostasisModelAssessmentofβ-cellfunction.Results:Thelevelsoftheage,systolicbloodpressure,fastinginsulinandHOMA-IRandtheprevalenceofhypertensioninpatientswithbraininf

4、arctionwerehigherthanthoseinpatientswithoutbraininfarctionascontrolsubjects(P<0.05).Adjustingforotherriskfactors,HOMA-IRwasalsoassociatedwithbraininfarctionandthissuggestedthatHOMA-IRwastheindependent上海交通大学医学院硕士学位论文VIIIriskfactorforbraininfarctioninamultivariatelogisticregressionanalysis，andapea

5、rsoncorrelationanalysisrevealedthatfastinginsulinandHOMA-βinpatientswithbraininfarctionwerepositivelycorrelatedwithHOMA-IR,andamultipleregressionanalysisrevealedthatfastingbloodglucose,insulin,C-peptideandHOMA-βinpatientswithbraininfarctionwerecorrelatedwithHOMA-IR.Conclusion:Insulinresistancewa

6、scloselycorrelatedwithbraininfarctioninnon-diabeticmiddle-agedandolderpeople.Itispossiblyinvolvedintheoccurrenceofbraininfarctionthroughcomplexmechanisms.Keywords:insulinresistance;braininfarction上海交通大学医学院硕士学位论文X专业词汇及缩略词索引表英文缩写英文全称中文全称FPGFastingplasmaglucose空腹血糖FINSFastinginsulin空腹血胰岛素FCortisol皮

7、质醇GHGrowthhormone生长激素CPC-peptideC肽TCTotalcholesterol总胆固醇TGTriglyeride甘油三脂LDLLow-densitylipoprotein低密度脂蛋白HDLHighdensitylipoprotein高密度脂蛋白ApoAApolipoproteinA载脂蛋白AApoBApolipoproteinB载脂蛋白BLP(a)lipoproteina脂蛋白a上海交通大学医学院硕士学位论文III上海