短暂性脑缺血发作与颈内动脉内中膜厚度相关性的初步研究

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1、短暂性脑缺血发作与颈内动脉内中膜厚度相关性的初步研究【摘要】目的探讨短暂性脑缺血发作继发脑梗死与颈内动脉内中膜厚度的关系。方法回顾性分析短暂性脑缺血发作（TIA）的患者90例。所有患者均行颈部超声检查，并随访一个月，了解其脑梗死发生情况。采用受试者工作特征曲线（ROC）分析颈内动脉内中膜厚度预测TIA继发脑梗死可能。结果颈内动脉内中膜厚度为（0.96±0.18）mm，随访１月后TIA患者发生脑梗死16例（发生率约17.8%），内中膜增厚组与未增厚组脑梗死发生率不同（c2＝4.514，Ｐ＜0.05）；颈内动脉内中膜厚度预测TIA继发脑梗死价值的ROC曲线下面积为0.73（P＜0.05）。结论TI

2、A患者具有较高的颈内动脉粥样硬化发生率，颈内动脉内中膜增厚对预测TIA继发脑梗死的发生有一定价值。【关键词】：短暂性脑缺血发作;颈内动脉内中膜厚度；脑梗死PreliminarystudyofthecorrelationoftransientischemicattackandcarotidarterythicknessLiuXudong1;ZhangZiyin2;1DepartmentofNeurological;ZiyangFristPeople’sHospital;Ziyang,Sichuan;641300;China2DepartmentofNeurosurgery,AffiliatedH

3、ospitalofHainanMedicalCollege,Haikou,Hainan,570102,China.Correspondingauthor:ZHANGZiyin,Email:270883089@qq.com[Abstract]ObjectiveToinvestigatethecorrelationbetweencarotidarteryintima-mediathicknessandcerebralinfarctionsecondarytotransientischemicattack.MethodsAretrospectiveanalysisof90casesinATIwasd

4、oneseriously.Allthecasesunderwentneckultrasonography,andfollowedupforonemonthinordertounderstandtheincidenceofcerebralinfarction.Wetrytofindthepossibilitythatusingreceiveroperatingcharacteristiccurves(ROC)analysisofcarotidarteryintima-mediathicknesstopredicttheoccurrenceofcerebralinfarctionsecondary

5、theTIA.ResultsThemeancarotidintima-mediathicknessofallthecaesewas(0.96±0.18)mm.Afterfollowedupforonemonth,16caseshadcerebralinfarction(17.8%).Theincidencerateofcerebralinfarctionaredifferencesbetweenintima-mediathickeninggroupandnothickeninggroup(c2＝4.514,Ｐ＜0.05).Theareaunderthe5curveofROCwhichbiuld

6、edbycarotidarteryintima-mediathicknessandcerebralinfarctionsecondarytoTIAis0.73（P＜0.05）.ConclusionsTIApatientshavehigherincidenceofcarotidatherosclerosis.Carotidarteryintima-mediathicknesshasacertainvalueinpredictingcerebralinfarctionsecondarytoTIA.[Keywords]Transientischemicattack；Carotidintima-med

7、iathickness；Cerebralinfarction短暂性脑缺血发作（transientischemicattack，TIA）是临床常见的脑血管病，是脑卒中的高危因子。相关研究表明，约10%~15%的TIA患者在3个月内罹患卒中，其中约50%患者发病在TIA后48小时之内[1]。因此，对TIA患者行早期相关检查及风险评估十分重要，为此本研究对TIA预后与颈内动脉内中膜厚度的相关性进行了初步