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1、MBEAdvanceAccesspublishedDecember20,20061GeneticevidencefortheconvergentevolutionoflightskininEuropeansandEastAsians1,8HeatherL.Norton2RickA.Kittles3EstebanParra4PaulMcKeigue1XianyunMao5,6KeithChengDownloadedfrom6VictorA.Canfield7DanielG.Bradleyhttp://mbe.oxfordjournals.org/7BrianMcEv
2、oy1MarkD.Shriver1DepartmentofAnthropologybyguestonMarch2,2013ThePennsylvaniaStateUniversity409CarpenterBuildingUniversityPark,PA168022DepartmentofMedicineSectionofGeneticMedicineTheUniversityofChicago5841SouthMarylandAvenueAMBW601~MC6091Chicago,IL60637USA3DepartmentofAnthropologyÓTheA
3、uthor2006.PublishedbyOxfordUniversityPressonbehalfoftheSocietyforMolecularBiologyandEvolution.Allrightsreserved.Forpermissions,pleasee-mail:journals.permissions@oxfordjournals.org2UniversityofTorontoatMississaugaMississauga,OntarioLSL1C6,Canada4ConwayInstituteUniversityCollege,DublinD
4、ublinIreland5JakeGittlenCancerResearchFoundation,DepartmentofPathologyThePennsylvaniaStateUniversityCollegeofMedicineHershey,PADownloadedfrom6DepartmentofPharmacologyThePennsylvaniaStateUniversityCollegeofMedicinehttp://mbe.oxfordjournals.org/Hershey,PA7SmurfitInstituteofGeneticsTrini
5、tyCollege,DublinIrelandbyguestonMarch2,20138currentaddress:ARL-BiotechnologyUniversityofArizona1041EastLowellRoadBiosciencesWest,Room246Tucson,AZ85721Runningtitle:ConvergentevolutionoflightskinCorrespondingauthor:HeatherL.Norton3ARL-BiotechnologyUniversityofArizona1041EastLowellRoadBi
6、osciencesWest,Room246Tucson,AZ85721Fax:(520)626-8050Phone:(520)621-9791Email:hnorton@email.arizona.eduDownloadedfromResearchArticlehttp://mbe.oxfordjournals.org/Keywords:skinpigmentation,naturalselection,convergentevolutionRunninghead:convergentevolutionoflightskinphenotypebyguestonMa
7、rch2,20134ABSTRACTHumanskinpigmentationshowsastrongpositivecorrelationwithultravioletradiation(UVR)intensity,suggestingthatvariationinskincoloris,atleastpartially,duetoadaptationvianaturalselection.Weinvestigatedtheevolutionofpigmentationvariationbytestingforthepresenceofpositivedirec
8、tiona
