Jinam2012 Evolutionary history of continental South East Asians- early train hypothesis based on genetic analysis of mitochondrial and autosomal DNA data

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1、MBEAdvanceAccesspublishedJune22,2012Title:EvolutionaryhistoryofcontinentalSouthEastAsians:"earlytrain"hypothesisbasedongeneticanalysisofmitochondrialandautosomalDNAdata1,23453TimothyA.Jinam,Lih-ChunHong,MaudeE.Phipps,MarkStoneking,MahmoodAmeen,62,1JuliEdo,ThePan-AsianSNPC

2、onsortium,NaruyaSaitou1DepartmentofGenetics,TheGraduateUniversityforAdvancedStudies(SOKENDAI),Mishima,411-8540Japan2DivisionofPopulationGenetics,NationalInstituteofGenetics,Mishima,411-8540Japan3DepartmentofMolecularMedicine,FacultyofMedicine,UniversityofMalaya,50603Kuala

3、Lumpur,Malaysia.4JeffreyCheahSchoolofMedicineandHealthSciences,MonashUniversity(SunwayCampus),46150Selangor,Malaysia5DepartmentofEvolutionaryGenetics,MaxPlanckInstituteforEvolutionaryAnthropology,DeutscherPlatz6,D-04103Leipzig,Germany6DepartmentofAnthropology,FacultyofArt

4、sandSocialSciences,UniversityofMalaya,50603KualaLumpur,MalaysiaTobesubmittedasaResearchPaperRunningtitle:“EarlyTrain”hypothesisforevolutionofSoutheastAsiansCorrespondingauthor:NaruyaSaitouDivisionofPopulationGenetics,NationalInstituteofGenetics,Mishima,411-0831JapanTel:+8

5、1-55-981-6790Fax:+81-55-981-6789Email:saitounr@lab.nig.ac.jpKeywords:Austronesian,Negrito,mitochondrialDNA,SoutheastAsia,OrangAsliTheAuthor2012.PublishedbyOxfordUniversityPressonbehalfoftheSocietyforMolecularBiologyEvolution.Allrightsreserved.Forpermissions,pleasee-mail:

6、journals.permissions@oup.com1ABSTRACTThepopulationhistoryoftheindigenouspopulationsinislandSoutheastAsiaisgenerallyacceptedtohavebeenshapedbytwomajormigrations;theancient‘OutofAfrica’migration~50,000yearsbeforepresent(YBP)andtherelativelyrecent‘OutofTaiwan’expansionofAust

7、ronesianagriculturalistsapproximately5,000YBP.TheNegritosarebelievedtohaveoriginatedfromtheancientmigrationwhereasthemajorityofislandSoutheastAsiansareassociatedwiththeAustronesianexpansion.Wedetermined86mitochondrialDNA(mtDNA)completegenomesequencesinfourindigenousMalays

8、ianpopulations,togetherwithareanalysisofpublishedautosomalsinglenucleotidepolymorphism(SNP)datao