多肿瘤标志物的联合检测和分析对胰腺癌诊断的价值探讨

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1、多肿瘤标志物的联合检测和分析对胰腺癌诊断的价值探讨作者：夏锋郑姬王曙光董家鸿【关键词】肿瘤【摘要】目的探讨肿瘤标志物的联合检测和分析对胰腺癌诊断的价值。方法应用蛋白芯片技术同时检测CA19-9、CEA、CA242、β-HCG、AFP、Free-PSA、Ferritin、NSE、PSA、CA125、CA15-3和HGH共12种肿瘤标志物在患者血清中的表达。试验分3组:胰腺癌组81例，良性胰腺病组57例，正常对照组547例。结果12种肿瘤标志物在胰腺癌、良性胰腺病和健康对照组之间表达的差异明显。总的表达强度为胰腺癌组>良性胰腺病组>健康对照组。胰腺癌组中CA19-9、CE

2、A、CA242、β-HCG、AFP、CA125和HGH的表达强度显著高于良性胰腺病组（P<0.05）。同时CA19-9、CEA、CA242、Fer-ritin、β10-HCG、AFP、CA125、HGH和CA15-3的阳性率也明显高于良性胰腺病组（P<0.05）。CA242、CA19-9、CEA和CA125对胰腺癌诊断的敏感性均高于50%，特异性均高于70%，准确性均高于60%。其中以CA242的敏感性、特异性和准确性最高，分别为72.8%、89.5%和79.7%。同时CA242、CA19-9和CEA联合检测的敏感性和准确性较之单项检测明显升高。两两联合的准确性均为8

3、5.9%以上，3种联合准确性则高达97.8%。结论肿瘤标志物CA242、CA19-9和CEA的联合检测可明显提高胰腺癌的诊断率。【关键词】胰腺癌;肿瘤标志物;蛋白芯片Clinicalsignificanceof12tumormarkersdetectionusingproteinbiochipinthediagnosisofpancreaticcarcinomaXiaFeng，ZhengJi，WangShuguang，DongJiahong.InstituteofHepatobiliarySurger-y&SouthwestHospital，ThirdMilitaryMe

4、dicalUniversity，Chongqing400038，China【Abstract】ObjectiveTodiscusstheclinicalsignificanceofmulti-tumormarkersdetectionusingproteinbiochipinthediagnosisofpancreaticcarcinoma.Methods12serumtumormarkers（CA19-9，CEA，CA242，β-HCG，AFP，Free-PSA，Ferritin，NSE，PSA，CA125，CA15-3andHGH）in81pa-tientswithpancr

5、eaticcarcinoma，57patientswithbenignpancreaticdiseaseand547healthyvolunteersweredetectedbyusingProteinChip.ResultsTherewassignificantdifferenceintheexpressionofthe12tumormarkersamongthethreegroups.TheexpressionoftumormarkersCA19-9，CEA，CA242，β-HCG，AFP，CA125andHGHinthecarcinomagroupwasmarkedlyst

6、rongerthaninthebenigngroup（P<0.05），andthesameasthepositiverateoftumormarkersCA19-9，CEA，CA242，Ferritin，β-HCG，AFP，10CA125，HGHandCA15-3（P<0.05）.ThesensitivityofCA242，CA19-9，CEAandCA125forpancreaticcarcinomawasmorethan50%，thespecificitywasmorethan70%，andthevaliditywasalsomorethan60%.CA242is

7、thetumormarkerwiththehighestsensitivity，specificityandvalidityof72.8%，89.5%and79.7%，respectively.ThesensitivityandvalidityofcombineddetectionofCA242，CA19-9andCEAwereimproved.Thevalidityofcombineddetectionoftwoofthethreemarkerswasmorethan85.9%