不同标本肿瘤标志物联合检测对肺癌的诊断价值

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1、·1838·刘大鹰，等不同标本肿瘤标志物联合检测对肺癌的诊断价值不同标本肿瘤标志物联合检测对肺癌的诊断价值1122刘大鹰，胡灼君，农天雷，林敏Diagnosticvalueofcombinedtumormarkersassaysindifferentsamplespatientswithlungcancer1122LIUDaying，HUZhuojun，NONGTianlei，LINMin12DepartmentofRespiration;DepartmentofNuclearMedicine，LiutieCentralHospitalofLiuzh

2、ouCity，GuangxiLiuzhou545007，China．【Abstract】Objective:Toevaluatetheclinicalsignificanceofassayingcarcino－embryonicantigen(CEA)，car-bohydrateantigens(CAl25andCAl9－9)andCytokeratin19fragment(CYFRA21－1)inserum，sputum，broncho－alveolarlavagefluid(BALF)andpleuraleffusionofpatientswit

3、hlungcancer．Methods:Usingthemethodofche-mi－luminescentenzymeimmunoassaywithacommerciallyavailableenzymeimmunoassaykit，52caseswithlungcancerand46caseswithbenignlungdiseasesunderwentassayofCEA，CA125，CA199andCYFRA21－1inserum，sputum，BALFandpleuraleffusion．Results:Ofthe52caseswithlu

4、ngcancer，thepositivepercentagesofcombinationassaysofCEA，CA125，CA199andCYFRA21－1wereasfollows:69．2%inserum，90．4%insputum，88．5%inBALFand82．1%inpleuraleffusion，respectively;Butthepositivepercentagesofthosewithbenignlungdiseaseswere19．6%，26．1%、23．9%，21．7%，respectively．Thepositivepe

5、rcentagesofcombinationofthesetumormarkersassaysinpatientswithlungcancerwassignificantlyhigherthaninthosewithnonmalignantrespiratorydiseases(P＜0．05)．Amongthe52patientswithlungcancer，thediagnosticsensitivityofcombinationofthesetumormarkersassaysinsputumorBALFwassignificantlyhighe

6、rthanthoseinserum(P=0．01;P=0．02)．Comparedwiththesingleser-umsamplesthatthesetumormarkersweremeasured，thecombinationof2or3ofthesesamplescouldimprovethesensitivityandaccuratevalueinthediagnosisoflungcancer(P＜0．05)．Conclusion:ToassayCEA，CA125，CA199andCYFRA21－1inserum，sputum，BALFan

7、dpleuraleffusionwasavaluableaidindiagnosisoflungcancer，andcomparedwiththesingleserumsamplethatthesetumormarkersweremeasured，thecombinationof2or3ofthesesamplescouldimprovesensitivityandaccuratevalueinthediagnosisoflungcancer．【Keywords】lungneoplasm;tumormarkers;serum;sputum;bronc

8、hoalveolarlavagefluid;pleuraleffusion;diagnosisModernO