q开关nd-yag激光联合重组人表皮生长因子治疗颧部褐青色痣疗效观察

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1、Q开关Nd:YAG激光联合重组人表皮生长因子治疗颧部褐青色痣疗效观察［摘要］目的：评价Q开关Nd:YAG激光联合重组人表皮生长因子(recombinanthumanepidermalgrowthfactor,rhEGF)在治疗颧部褐青色痣（naevusfuscocaeruleuszygomaticusNFZ）过程中对减轻色素沉着，缩短疗程的作用。方法：对2004年12月～2007年12月采用Q开关Nd:YAG激光治愈的52例颧部褐青色痣患者的临床资料进行回顾性分析，治疗组27例（治疗后外涂重组人表皮生长因子），

2、对照组25例（治疗后待自然愈合），比较其治疗间隔时间、疗程的长短。结果：治疗组与对照组平均治疗间隔时间分别为74.59天及105.24天，平均疗程分别为453.37天及651.28天，两组差异有统计学意义（P＜0.05）。结论：Q开关Nd:YAG激光联合重组人表皮生长因子治疗颧部褐青色痣色素沉着轻、疗程较短，值得临床推广。［关键词］Q开关Nd:YAG激光；颧部褐青色痣；重组人表皮生长因子；疗效[中图分类号]R758.51[文献标识码]A[文章编号]1008-6455（2008）06-0892-03Theobse

3、rvationoftheraperticeffectofnaevusfuscocaeruleuszygomaticustreatedbyQ-switched9Nd:YAGlaserassociatedwithrecombinanthumanepidermalgrowthfactorYANGHai-bo，LIDa-tie,ANLi-sha,WENYang,TANGZheng-xi(DepartmentofCosmeticLaser,theCosmeticHospitaloftheAffiliatedHospita

4、lofZunyiMedicalCollege,Zunyi563003,Guizhou,China)Abstract:ObjectiveToevaluatethetherapeuticeffectofnaevusfuscocaeruleuszygomaticustreatedbyusingQ-switchedNd:YAGlaserassociatedwithrecombinanthumanepidermalgrowthfactortolessenpigmentationanddecurtatecourseoftr

5、eatment.MethodsToreviewandanalysizetheclinicaldataof52patientswithNFZwhichhavebeenrecoveredinthepastyearsrangedfrom2004.12to2007.12.Allthecasesweredividedintotwogroups:thetherapicgroupwith27caseswereappliedrhEGFafterthetreatmentandthecontrolgroupwith25casesw

6、erehealedradomlytocompareintervaltimeandcourseoftreatment.ResultsTheaverageintervaltimeofthetherapicgroupandthecontrolgroupwasrespectively74.59daysand105.24days,9andtheaveragetimeoftherapyofbothgroupswasrespectively453.37daysand651.28days.Thedifferenceofthem

7、wasstatisticalsignificance（P＜0.05）.ConclusionThetherapicmethodofNFZbyQ-switchedNd:YAGlaserassociatedwithrhEGF.isworthgeneralizationinclinicbecauseoflesspigmentationandshortertimeoftherapyKeywords:Q-switchedNd:YAGlaser;naevusfuscocaeruleuszygomaticus;recombin

8、anthumanepidermalgrowthfactor;therapeuticeffect颧部褐青色痣（naevusfuscocaeruleuszygomaticus，NFZ）是对称分布于双侧颧部、颞部、上眼睑外侧，呈青褐色、棕褐色及黄褐色群集而不融合的圆形或卵圆形的色素性皮肤病。传统的治疗方法，如冷冻、磨削、化学剥脱术等疗效不佳。目前认为应用Q开关Nd:YAG激光治疗NFZ是一种