n-3系多不饱和脂肪酸对人体健康的

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1、Thehealthbenefitsandpotentialharmfuleffectsofn-3polyunsaturatedfattyacids(PUFAs)onhumanbody张清B11207120导师：沈群ContentsWhatisthen-3PUFAs?What’sthehealthbenefits?What’sthepotentialharmfuleffects?What’stheequilibriumpoint?1n-3polyunsaturatedfattyacids(PUFAs)C18-22n-xorωxwhere

2、xisthedoublebondcarbonnearestthemethylendarewidelyusedinthecurrentbiomedicalliteratureandwidernutritionalcontexts.Marineandplantsources:fish,nuts,seedsetc.n-3andn-6PUFAsn-6:linoleicacid(LA)andArachidonicacid(AA)(20:4)n-3:α-linolenicacid(LN),eicosapentaenoicacid(EPA)(20:

3、5)anddocosahexaenoicacid(DHA)(22:6)2.1Biochemicalpathwaysofn-3andn-6FAswiththeireffectsonmetabolismAnti-inflammatorySleepinducerPGE1,PGE3,PGI3,thromboxane(血栓烷)A3,pentaenoicleukotrienes,PGD2EFACholesterolAA(n-6)CytochromeP450/liverLN(n-3)LA(n-6)Dihomoα-LN(n-3)Prostagland

4、in(前列腺素,PG)E2;Leukotrienes(白三烯),Interleukin(白介素)-2(IL-2),IL-6,Tumournecrosisfactor,ThromboxaneA2TumourgrowthVascularpermeabilityPlateletaggregationOedema(水肿)Inflammatory&immunosuppressive2.2Currentapplicationfieldsofn-3PUFAsn-3PUFAsAerospaceindustryCardiovasculardisease:

5、Atherosclerosis(动脉粥样硬化),arterialfibrilosis,thromboses,andemboliCancer(especiallyingastrointestinalsource)Diabetestype2Depression&stressInflammation:crohn’sdisease,rheumatoidarthritis(风湿新关节炎),asthma(哮喘),multiplesclerosis(多发性硬化),chronicglomerulardisease(慢性肾小管疾病),erythemat

6、osus(全身性红斑狼疮),eczema(湿疹),InflammatoryBowelDisease(IBD)(炎性肠病)Brainhealthandneurologicaldisorders:AlzheimerDiseasePre/postoperativeperiodsinsurgeryInfantnutritionEyehealth2.2.1Anti-inflammatorypropertiesofn-3PUFAsn-3PUFAsPostoperativeperiods:Mediateposttraumaticimmunedysre

7、gulation;Ameliorateshostdefencemechanisms;ControllinginflammatoryresponseCrohn’sdisease:Inhibitionofproinflammatorycytokine(促炎细胞因子);Reducesmucosaldamage;HealingofcolonmucosaControlsurgery-inducedimmunosuppression(免疫抑制)DecreaseplateletaggregationandthrombosisDHA:increasing

8、effectinneutrophil(嗜中性粒细胞)proliferationandmonocytephogocytosis(吞噬活性)DecreasethepainexperienceinpatientsReduceac