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1、无症状脑白质疏松患者局部脑血流的定量评借80中田临床康复第善第期2006-03-15出版ChineseJournalofClinicalRehabilitation,March152006VoL10No.10无症状脑白质疏松患者局部脑血流的定量评估★郑莉莎,许晶,王俊平?基础研究?大连医科大学附属第一医院神经内科,辽宁省大连市11601l郑莉莎★,士,1972年生,吉林省长春市人,1999年大连医科大学毕业,硕士,主要从事老年期痴呆方面的研究.中圈分类号;R743文献标识码.A文章编号:1671—5926(2006)10一~)80-03收稿日期:2005一l2-l4修回13期:2006-01一
2、l7(O55Ol1—8905/J?L)QuantitativeevaluationofregionalcerebralbloodflowinpatientswithsilentLeukoaralosisZhengLi-sha,XuJing,WangJun—pingDepartmentofNeurology,FirstAmlistedHospital,DalianMedicalUniversity.Dalian1160l1,LiaoningProvince,ChinaZhengLi-sha★,Master,DepartmentofNeurology,FirstAffiliatedHospita1
3、.DalianMedicalUniversity,Dalinn116011,LiaoningProvince,ChinaR~ceived:2o05—12—14Accepted:2006一Ol一17Abstract删:Todetectthecerebralbloodflow(CBF1ofpatientswithsilentLeukoaraiosistoobservethechangesoftheircerebralcirculationandcerebralfunetion.M哐THoDS:ThemeanCBFa-dregionalCBFwerequantitativelydetectedwit
4、hrc—ECDandconsecutivesinglephotonemissioneomputerizedtomography(SPECT)in20patientswithsilentLeukoaraiosisand15normalelderlypeople.ThepatientswithsilentLeukoaraiosisweItheoutpatientsorinpatientsoftheDepartmentofNeurology.theFirstA脏liatedHospitalofDalJanMedicalUniversitybetweenAugust2001andJanuary2003
5、.andthenormalelderlypeopleweI'etheelderlyheahhyphysicalexamineesinthishospita1.At30minutesbeforeSPECT.allthesubjectsorallytookpotassiumperchloratef200—400mg)toreducetheuptakeofdeveloperbychoroidsplexus,salivaryglandandthyroidgland,inordertoavoidaffectingthequalityofimage.Thedeveloperwasinfusedviaelb
6、owveininapelletmanner,anddynamiccollectionwaspedbrmedimmedlately.Spotsourceswereplacedatexternale0A-holeandlateralcnnthustostaticallycollectedcerebralparcnchymafor30s,soastodefinetheorbitomeatal(OM1line.andcollectedwtthSPECT.Theimagereconstructionwasappliedtotheoriginaldata.andtheSPECTimagewastreate
7、dwithLassencorrectionafterthemesllCBFwasobtained,andthenthequantitativeimagewascolletted.'Weselectedthreetransaxialslicesabovethe0M1ineat50mm,60mmand70mm,respectively,/md20regionsofinterest(ROIs)weres
