毕业设计（论文）-p53基因的研究进展

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1、届别2011届学号毕业设计（论文）P53基因的研究进展姓名系别专业化生系生物技术导师姓名职称讲师完成时间2011年4月28日目录摘要····················································ⅠAbstract················································Ⅱ1P53基因概述··········································•11.1P53基因的发现····································

2、··11.2P53基因的命名·····································•11.3P53基因的研究史·······························•·••21.4研究动态········································•••32P53基因结构和表达·····································42.1基因的结构·······································••42.2基因的表达················

3、······················••·52.3基因的失表达····································••·63P53基因的功能·····································•••·73.1阻滞细胞周期··································••••·73.2促进细胞凋亡··································••••·73.3维持基因稳点·································•••••·83.

4、4抑制肿瘤血管生成·····························•••••·83.5信号通路·······································•••·94P53用于治疗方面································•••··•••104.1基因疗法···········································104.2重建P53蛋白活性···································124.3P53治疗效果················

5、·······················135P53基因最新研究·······································14参考文献················································18致谢····················································19摘要从1979年发现至今，P53已经历经30多年的岁月，30年说长不长说短不短，人们对p53基因的认识经历了癌蛋白抗原—癌基因—抑癌基因的三重转变，关于p53的文章层出不穷，每当

6、我们觉得离p53的真相接近之时才发现，p53仍是我们最熟悉的陌生人。最近的Nature，PNAS分别发表了p53最新研究进展，再度拉近了我们与p53真相间的距离。关键字：P53基因；肿瘤；基因治疗；重组蛋白IIAbstractFoundsofarin1979,P53hasbeenthrough30yearsofage,30yearscanbealongashorttime,people'sunderstandingofthep53genehasundergonecancerantigenprotein-oncogene-tumorsuppres

7、sorgeneinthetriplechange,withregardtop53'sArticleafteranotherwheneverwefeelthetruthfromthecloseofp53onlytofind,p53isstillourmostfamiliarstrangers.RecentNature,PNASpublishedp53wererecentprogress,weonceagainclosertothedistancebetweenthetruthandp53.Keywords:P53gene;tumor;geneth

8、erapy;recombinantproteinII1P53基因概述1.1P53基因的发现1979年，在大家都在研究SV40病毒的癌蛋白时，好几个科研