糖尿病胰岛素治疗方案（insulin therapy for diabetes mellitus）

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1、糖尿病胰岛素治疗方案（Insulintherapyfordiabetesmellitus）ThediabeticinsulintherapySelectionofinsulintypes*animalinsulinisextractfromanimalpancreaspurifiedthroughaseriesofprocessessuchasproduction,thepeoplebelongstotheheterogeneousproteinhasstrongimmunogenicityandmaycausesensitization,long-termusemayha

2、veledtoreducedefficacyofantibody.Recombinanthumaninsulinisabiologicalengineeringdrugproducedbygenerecombinationtechnology.Ithasthesamestructureandbiologicalactivityashumanendogenousinsulin.*recombinanthumaninsulinanaloguesofaminoacidstructureofaminoacidmodificationtechnologyofrecombinanthu

3、maninsulininthehumanbody,canchangethepharmacokinetics,accelerateorextendtheonsetordurationofactioninvivo,butbecauseofitsstructureandhumanendogenousinsulinisnotcompletelyconsistent,alsobelongtotheheterologouspolypeptideofpeopleitisimmunogenicandmaycausesensitization,orantibodiesleadtolessef

4、fective.Humaninsulinshouldbeusedinthefollowinggroups:AwomanwhohasbeenpregnantorintendingtohaveapregnancyAllergicpersonInsulinresistanceispresentinanimalsInsulintherapyhasjustbegunThosewhowishtoapplyinsulinintermittentlyLongtermuseofhumaninsulinanalogueswithreducedefficacyAnewpatientwhodoes

5、notknowthetypeofinsulinoriginallyusedInsulindeliveryregimen1,"insulinphysiologicalsupply"program,3~4injectionsperday(intensivetreatmentprogram)Fast/shortactinginsulin,premealinjection+medium/long-actinginsulin,beforegoingtobed,4injectionsperdayFast/shortactinginsulinisgiven3timesadaybefore

6、mealsBeforebreakfastandbeforedinner,takeaquick/shortactinginsulin+preoraloralhypoglycemicagent+bedtimemedium/long-actinginsulin,3timesadayPreinsulininjection+preinjection/shortactinginsulin+bedtimeinjection/medium/longactinginsulin,3injectionsperday,beforebreakfast2,1~2timesperdayinsulinin

7、jection(nonintensivetreatment)BIDOtreatment:bedtimeinjectionofmedium/longactinginsulin+oralhypoglycemicagentsduringthedayPremixedinsulinbeforebreakfast+premixedinsulinbeforedinnerBreakfast/quickactinginsulin+supper/shortactinginsulinBreakfastbeforespeed/shorta