多囊卵巢综合征患者瘦素、雄激素、胰岛素关系临床研究

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1、多囊卵巢综合征患者瘦素、雄激素、胰岛素关系临床研究作者：鲁晓燕,刘曼华,郑艳莉,陶潜单位：南通大学第二附属医院妇产科，南通226001【摘要】目的：通过研究多囊卵巢综合征(PCOS)患者血清瘦素(Leptin)、雄激素(T)、胰岛素(Ins)间关系，为临床辅助诊断及治疗提供理论依据。方法：选取PCOS患者55例为研究组，正常人群26例为对照组，均分成肥胖组与非肥胖组，同时PCOS患者随机分3组：A组服达英-35，B组达英-35+二甲双胍，C组曲谱瑞林，治疗3个月，均测定血清Leptin、T、Ins、黄体生成素(LH)、促卵泡素(FSH)水平，进行相关比较。结果：血清

2、Leptin、Ins、T、LH水平PCOS组均高于相当体重指数对照组;且Leptin水平在肥胖组高于非肥胖组，Ins水平在PCOS组内肥胖组高于非肥胖组;PCOS患者血清瘦素、雄激素、胰岛素间呈正相关性;达英-35治疗组T、Leptin下降;达英-35+二甲双胍组T、Leptin、Ins均下降;曲谱瑞林组T下降显著，Leptin有下降，Ins水平虽有所下降，但差异无统计学意义;组间比较曲谱瑞林组T水平下降最显著。结论：PCOS患者存在高雄激素、高胰岛素、高瘦素血症，三者间呈正相关性;达英-35联合二甲双胍可降低患者血清雄激素、瘦素、胰岛素水平;对PCOS顽固性高雄激

3、素及高瘦素者短期应用促性腺激素释放激素激动剂(GnRH-a)可能获得更好疗效。【关键词】多囊卵巢综合征;瘦素;雄激素;胰岛素Aclinicalstudyonthecorrelationamongleptin，testosteroneandinsulininwomenwithPCOS　　LUXiaoyan,LIUManhua,ZHENGYanli,etal(DepartmentofObstetricsandGynecology,theSecondAffiliatedHospitalofNantongUniversity,Nantong226001)　　[Abstrac

4、t]Objective:TodetectthecorrelationamongLeptin,testosterone(T),andinsulin(Ins)andtoputforwardtheoreticalsupportstoclinicalsubsidiarydiagnosisandtreatmentforwomenwithpolycysticovariansyndrome(PCOS).Methods:Thesubjectswere55patientswithPCOSand26normalcontrolwomen,bothofwhomwereclassifiedi

5、ntotwogroups:obesitygroupandnon-obesitygroup.Atthesametime,thePCOSwomenweredividedrandomlyintothreegroups:womeninGroupAweretreatedwithDiane-35,inGroupBwithDiane-35+metforminandinGroupCwithTriptorelinforthreemonths.Inallpatients,serumconcentrationsofhormonelevelsofleptin,T,Ins,LH,andFSH

6、weremeasuredtocomparetheirrelationship.Results:Itwasshowedthatserumleptin,Ins,TandLHthanthoseincontrolgroup,bothofwhichhavethesimilarBMI.What'smore,higherlevelofserumleptincouldbeobservedinobesiticgroupthanthoseinnon-obesiticone,.theirlevelsofserumLeptin,Ins,TinwomenwithPCOSwerehighert

7、hanthoseinnormalcontrolwomen.Therewasapositivecorrelationamongserumleptin,TandInsinwomenwithPCOS.ThelevelsofTandLeptinshowedadecreaseafterDiane-35wasadministered.WhilethelevelsofthesethreehormoneshadalldeclinedwithDiane-35+metforminadministered.AfterTriptorelinwasadministered,therewa