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1、900MHz电磁辐射对人胚肺细胞DNA及p53基因蛋白表达的影响2007??4?v?j24???j4?3JEnvironHealth,April2007,Vol.24,No.4?????.??:1001-5914(2007)04-0251-03900MHz?x?????4????????????DNA??p53???????????????????S??1,?????-2,????1,????1,???%??1????:?????p??900MHz?x?????4????????????DNA??p53?????
2、?????????????60?????L900MHz?x????????????60???????????x???????E?C1622625628mW/cm24?B???g??,?????d?c??????(0mW/cm2)???F?c??????(0.1mmol/L?????????4?E),????2?B?????u,???g?????=?C1h,???????I????DNA????????60WesternBlot?????E?C1622625628mW/cm24?B???g??,?????d?c??
3、????(0mW/cm2)???F?c??????(?????m?????BRaji),???g?????=?C12h,?????x?????4??p53??????????????????60?????a?d?c??????(0mW/cm2)????,?4???g???????I????DNA???????????0?????????l?<(P>0.05)60?4???g?????d?c??????(0mW/cm2)???????Pp53?????????C?d?c,?H?F?c??????????
4、?6??p53??????????60?????j?????B?????6900MHz?x?????4????????????DNA??p53?????????????i????60???>??:???4;DNA???m;p53?????P???E????:R994.6???>?n???2:AEffectsof900MHzElectromagneticFieldonDNAandtheProteinExpressionofp53GeneinHumanEmbryonicLungCellsFANGJun,H
5、UANGXiang-gang,MALing,etal.TheInstituteforEnvironmentalHealthandRelatedProductsSafety,ChinaCDC,Beijing100021,ChinaAbstract:ObjectiveTostudytheeffectsof900MHzelectromagneticfield(EMF)onDNAandtheproteinexpressionofp53geneinhumanembryoniclungcells.MethodsSinglec
6、ellgelelectrophoresis(SCGE)andWesternBlotwereusedfortheresearch.ResultsTheresultsshowedthat900MHzEMFcouldnotdamagetheDNAofhumanembryoniclungcellswhentheexposuretimewas1handtheexposuredoseswere1,2,5and8mW/cm2respectively]900MHzEMFcouldnotaffecttheproteinexpres
7、sionofp53geneinhumanembryoniclungcellswhentheexposuretimewas12handtheexposuredoseswere1,2,5and8mW/cm2respectively.ConclusionAttheexposuredosesinthepresentresearch,900MHzEMFneithercandamagetheDNAofcells,norcanaffecttheproteinexpressionofp53gene,sotheresultscan
8、notsustaintheissuethat900MHzEMFmaycausecancer.Keywords:Radiation]DNAdamage]p53gene???J?????P?????????g???G?P???????a?????????????????O(?N??);?P?????????g???G?P???c???????????g???G?P??(?N?
