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1、CT导引下植入^125Ⅰ放射性密封籽源治疗中晚期肺癌肿瘤研究与临床2006年6月第l8卷第6期CancerResearchandClinic,June20o6,Vo1.18,No.6CT导引下植入I放射性密封籽源治疗中晚期肺癌胡效坤邱眷东吕东方张广岭周志强王永奎刘元伟【摘要】目的探讨cT导引下植入I放射性密封籽源治疗中晚期肺癌的临床应用价值并进行随访评价.方法回顾分析72例失去手术机会的中晚期肺癌,运用治疗计划系统(TPS)按处方剂量设计籽源分布,全部病例行经静脉化疗2—6次.治疗后1,2,6个月及1年行CT随访评价.结果1个月后随访病灶缩小76处,_尢变化8处,
2、增大28处;2个月后随访病灶缩小84处,无变化4处,增大24处;6个月后随访病灶缩小98处,无变化2处,增大12处;1年后随访病灶缩小6O处,无变化0处,增大28处,6个月后失随访12例共24处.随访中,患者新发生转移4O例.随访6个月时生存率为100%(72/72),随访1年时生存率为85.71%(6O/7o).结论植入I放射性密封籽源治疗中晚期肺癌,操作安全,并发症少,6个月时临床疗效达到最佳,可重复进行,是综合治疗措施中值得应用的方法之一.【主题词】CT导引;I放射性密封籽源;肺癌【中图分类号】R734.2【文献标识码】A【文章编号】1006—9801(20
3、06)06—0376—04ThestudyandevaluationofcuringmetaphaseorterminallungcancerbyembeddingmIunderCTguidanceHU册一kun.QIUChun—dong,LuDong-fang,ZHANGGuang—ling,ZHOUZhi—qiang,WANGYong-kui,LIUYuan-wei.DepartmentofRadiology,QiluandHngyiUnionHospitalofShandongUniversity,Linyi273300,China【Abstract】Obj
4、ectiveTodiscusstheclinicalvalueandevaluatethroughcallbackaboutcuringmetaphaseorterminallungcancerbyembeddingIunderCTguidance.Methods72casesofmetaphaseorterminallungcancerwithoutthechanceofoperationhadbeenanalysed.ThedistributionofparticleshadbeendesignedthroughTPsaccordingtothedosages
5、ofprescription.Theevaluatethroughcallbackhadbeendonea:her1,2,6monthsand1year,ResultsAfter1month,76focihadbeenreduced,8focinochange,28focienlarged.After2months,84focihadbeenreduced,4focinochange,24focienlarged.After6months,98focihadbeenreduced,2focinochange,12focienlarged.After1year,60
6、focihadbeenreduced,0focinochange.28focienlarged,40newlocihadbeendiscoveredduringcallback,Therateoftheexistwas100%after6months.85.71%after1year.ConclusionItissafeanditscomplicationswerefewincuringmetaphaseorterminallungcancerbyembeddingIunderCTguidance.thecliniceffectisbestafter6months
7、ofcuring.Thiswaycanberepeated,anditisoneoftheintegrationcurewayandisworthyofusing.【subjectwords】Lungcancer;EmbeddingI;CTguidance我们采用以植入I放射性密封籽源治疗为主,结合经静脉化疗的综合治疗措施,对72例112个病灶进行治疗并随访,旨在探讨CT导引下植入I放射性密封籽源治疗中晚期肺癌的临床应用价值,并进行随访评价.1资料与方法1.1一般资料本组72例112处病灶,男44例,女28例.年龄45～84岁,中位年龄67岁.中心型肺癌44例,周
8、围型肺癌2
